DegronMD

Uniprot ID: Q13023

Source protein: A-kinase anchor protein 6

Source gene: AKAP6

Class: DEG_SCF_SKP2-CKS1_1

Location: 2241:2248

E3 ligase: SKP2,CSK1

DEGRON score: 0.6829

ASA_SCORE: 88.3375

COIL: 0.7679

CONS_SCORE: 0.4516

DSS_SCORE: 0.6516

HELIX: 0.1261

FCONS_SCORE: 0.9633

RIG_SCORE: 0.698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2239S	TCGA-33-6737	LUSC	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A2239S	DO26866	LUSC	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S2247L	TCGA-55-6968	LUAD	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.6556
p.S2247L	DO23759	LUAD	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.6556
p.E2240Q	TCGA-AO-A03M	BRCA	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E2240Q	DO2216	BRCA	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D2250G	TCGA-B5-A3FA	UCEC	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.D2250G	DO52402	UCEC	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G2257R	TCGA-CS-5394	LGG	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.0833
p.G2257R	DO22273	LGG	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.0833
p.G2257R	DO34032	PACA	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E2243K	TCGA-GN-A269	SKCM	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E2243K	DO37483	SKCM	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.7022
p.P2246L	TCGA-IH-A3EA	SKCM	TCGA	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P2246L	DO220881	MELA	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P2246L	DO37667	SKCM	ICGC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.7582
p.N2241D	SIDM00061	Ovarian Carcinoma	GDSC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.5821
p.K2248N	SIDM00574	Glioblastoma	GDSC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.6918
p.K2248N	ACH-001605	Brain Cancer	CCLE	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.6918
p.K2248N	no-10	central_nervous_system	COSMIC	NLEFTPSK	DEG_SCF_SKP2-CKS1_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13023	A-kinase anchor protein 6	DEG_SCF_SKP2-CKS1_1	2241:2248	NLEFTPSK	SKP2,CSK1	0.6829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons