DegronMD

Uniprot ID: Q13023

Source protein: A-kinase anchor protein 6

Source gene: AKAP6

Class: DEG_Kelch_Keap1_1

Location: 326:331

E3 ligase: KEAP1

DEGRON score: 0.7982

ASA_SCORE: 78.3

COIL: 0.768

CONS_SCORE: 0.3905

DSS_SCORE: 0.6238

HELIX: 0.2025

FCONS_SCORE: 0.8074

RIG_SCORE: 0.6102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L333V	TCGA-C5-A1MH	CESC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.L333V	DO48982	CESC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.G324W	TCGA-ER-A19Q	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.G324W	DO47497	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.A337V	DO228483	BRCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO229010	COCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO229346	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO230659	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO225404	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO231140	LAML	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO229047	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A337V	DO52365	LUSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.S328F	DO233682	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons