DegronMD

Uniprot ID: Q9P1Z0

Source protein: Zinc finger and BTB domain-containing protein 4

Source gene: ZBTB4

Class: DEG_Kelch_Keap1_1

Location: 825:830

E3 ligase: KEAP1

DEGRON score: 0.9877

ASA_SCORE: 76.3333

COIL: 0.8222

CONS_SCORE: 0.6364

DSS_SCORE: 0.7553

HELIX: 0.0692

FCONS_SCORE: 1.1621

RIG_SCORE: 0.5543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G834E	TCGA-AP-A0LN	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834E	DO41614	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834W	TCGA-BF-A1PX	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834W	TCGA-DZ-6133	KIRP	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834W	TCGA-EB-A24C	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834W	DO20762	KIRP	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834W	DO37438	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.G834W	DO51236	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.A818D	TCGA-D3-A3MR	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.A818D	DO47256	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.S827F	TCGA-FS-A1ZZ	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.7982
p.S827F	DO37412	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7982
p.E821Q	TCGA-JW-A5VL	CESC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.E821Q	DO49976	CESC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.A818S	DO224847	BRCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.A818S	DO227473	BRCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.E821D	DO233828	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.M822L	DO233828	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.P819L	DO228478	MALY	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons