DegronMD - O43365(HOXA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P186S	TCGA-A5-A0G2	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0833
p.P186S	DO41235	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0833
p.K167N	TCGA-A5-A0G2	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation substituting flanking lysine	0.3056
p.K167N	DO41235	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation substituting flanking lysine	0.3056
p.G176C	TCGA-AP-A1DK	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation altering degron motif	0.76
p.G176C	DO42033	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation altering degron motif	0.76
p.A180D	TCGA-CK-4951	COAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.25
p.A180D	DO10582	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.25
p.S162F	TCGA-DU-6392	LGG	TCGA	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0556
p.S162F	DO22237	LGG	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0556
p.R163Q	TCGA-EO-A22R	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0833
p.R163Q	DO42713	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0833
p.D182N	DO234157	ESAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.1944
p.Q168K	DO229029	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.2222
p.T166K	DO229009	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.1667
p.A180T	DO228138	PBCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.25
p.S174N	DO232761	PBCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation altering degron motif	0.7069
p.P186L	SIDM01394	Kidney Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0833
p.P186L	ACH-000907	Kidney Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.0833

Kaplan plot for HOXA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXA3

UniProt ID: O43365

Entrez ID: 3200

Protein name: Homeobox protein Hox-A3 (Homeobox protein Hox-1E)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXA3 in