DegronMD

Uniprot ID: O43365

Source protein: Homeobox protein Hox-A3

Source gene: HOXA3

Class: DEG_Kelch_Keap1_1

Location: 172:177

E3 ligase: KEAP1

DEGRON score: 0.9946

ASA_SCORE: 74.25

COIL: 0.8842

CONS_SCORE: 0.5518

DSS_SCORE: 0.6885

HELIX: 0.0732

FCONS_SCORE: 1.0459

RIG_SCORE: 0.5214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P186S	TCGA-A5-A0G2	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.P186S	DO41235	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.K167N	TCGA-A5-A0G2	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.K167N	DO41235	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.G176C	TCGA-AP-A1DK	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.76
p.G176C	DO42033	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.76
p.A180D	TCGA-CK-4951	COAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.A180D	DO10582	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.S162F	TCGA-DU-6392	LGG	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.S162F	DO22237	LGG	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.R163Q	TCGA-EO-A22R	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.R163Q	DO42713	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.D182N	DO234157	ESAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q168K	DO229029	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.T166K	DO229009	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.A180T	DO228138	PBCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.S174N	DO232761	PBCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7069
p.P186L	SIDM01394	Kidney Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.P186L	ACH-000907	Kidney Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons