DegronMD

Uniprot ID: Q86Z02

Source protein: Homeodomain-interacting protein kinase 1

Source gene: HIPK1

Class: DEG_Kelch_Keap1_1

Location: 167:172

E3 ligase: KEAP1

DEGRON score: 0.5636

ASA_SCORE: 78.7

COIL: 0.8977

CONS_SCORE: 0.5343

DSS_SCORE: 0.4624

HELIX: 0.042

FCONS_SCORE: 0.9167

RIG_SCORE: 0.6157

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V178I	TCGA-AP-A051	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.V178I	DO42673	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.T164I	TCGA-FD-A3SL	BLCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.T164I	DO732	BLCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.R170W	DO10092	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.8634
p.R170W	DO232761	PBCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.8634
p.R170W	DOK	upper_aerodigestive_tract	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.8634
p.E166G	DO8264	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.Q163E	DO233190	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.R171K	DO14998	HNSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7237
p.I181M	DO24005	LUAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.S169F	DO229462	SKCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7982
p.E166D	DO42568	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.S170T	ACH-000600	Kidney Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons