DegronMD

Uniprot ID: Q92570

Source protein: Nuclear receptor subfamily 4 group A member 3

Source gene: NR4A3

Class: DEG_Kelch_Keap1_1

Location: 284:289

E3 ligase: KEAP1

DEGRON score: 0.8454

ASA_SCORE: 78.65

COIL: 0.9008

CONS_SCORE: 0.5663

DSS_SCORE: 0.38

HELIX: 0.0608

FCONS_SCORE: 0.8418

RIG_SCORE: 0.5113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S296L	TCGA-EB-A5UN	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.D297Y	DO50090	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1111
p.S279L	DO234227	ESAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1944
p.S279L	DO229462	SKCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1944
p.E289Q	DO233671	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.6744
p.V294M	DO233737	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1944
p.S285L	DO47267	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.6556
p.P275S	DO37432	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.A299T	DO47849	STAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.C295R	DO229121	THCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.P280Q	ACH-000712	Lung Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons