DegronMD - Q14493(SLBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V213L	TCGA-49-AARO	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.L215R	TCGA-BR-8589	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.L215R	TCGA-BR-8589	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.D231N	TCGA-CD-A486	STAD	TCGA	DDFDVYSGTP	CBL_PTK	230:239	Mutation altering degron motif	0.5821
p.H211Y	TCGA-XK-AAIW	PRAD	TCGA	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.S229C	DO48418	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.S229C	DO48418	BLCA	ICGC	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.3056
p.S229C	DO48418	BLCA	ICGC	DDFDVYSGTP	CBL_PTK	230:239	Mutation rewiring degron network	0.3056
p.Y242H	DO233737	GACA	ICGC	DDFDVYSGTP	CBL_PTK	230:239	Mutation rewiring degron network	0.25
p.S224Y	DO229028	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.712
p.S228R	DO229038	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.8538
p.V220L	DO218924	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6765
p.H218Y	DO51407	PRAD	ICGC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7229
p.D238N	DO47853	STAD	ICGC	DDFDVYSGTP	CBL_PTK	230:239	Mutation altering degron motif	0.6932
p.L222R	DO47813	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.8428
p.D226Y	ACH-000536	Breast Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7325
p.D226Y	BT-20	breast	COSMIC	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7325
p.C219W	ACH-000674	Gastric Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7
p.C219W	NUGC-4	stomach	COSMIC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7
p.D212Y	ACH-001127	Leukemia	CCLE	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.D212Y	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.D230Y	BT-20	breast	COSMIC	DDFDVYSGTP	CBL_PTK	230:239	Mutation altering degron motif	0.7325
p.D216Y	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.D216Y	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.1111
p.C223W	NUGC-4	stomach	COSMIC	AESSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.C223W	NUGC-4	stomach	COSMIC	PQTSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.3056
p.C223W	NUGC-4	stomach	COSMIC	DDFDVYSGTP	CBL_PTK	230:239	Mutation rewiring degron network	0.1389

Kaplan plot for SLBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLBP

UniProt ID: Q14493

Entrez ID: 7884

Protein name: Histone RNA hairpin-binding protein (Histone stem-loop-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLBP in