DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DDFDVYSGTP
Uniprot ID:
Q14493
Source protein:
Histone RNA hairpin-binding protein
Source gene:
SLBP
Class:
CBL_PTK
Location:
230:239
E3 ligase:
CBL
DEGRON score:
0.9997
ASA_SCORE:
80.82
COIL:
0.8399
CONS_SCORE:
0.2878
DSS_SCORE:
0.6255
HELIX:
0.1314
FCONS_SCORE:
1.0389
RIG_SCORE:
0.6713
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D231N
TCGA-CD-A486
STAD
TCGA
DDFDVYSGTP
CBL_PTK
0.5821
p.S229C
DO48418
BLCA
ICGC
DDFDVYSGTP
CBL_PTK
0.3056
p.Y242H
DO233737
GACA
ICGC
DDFDVYSGTP
CBL_PTK
0.25
p.D238N
DO47853
STAD
ICGC
DDFDVYSGTP
CBL_PTK
0.6932
p.D230Y
BT-20
breast
COSMIC
DDFDVYSGTP
CBL_PTK
0.7325
p.C223W
NUGC-4
stomach
COSMIC
DDFDVYSGTP
CBL_PTK
0.1389
Drug responses associated with SLBP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDFDVYSGTP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14493
Histone RNA hairpin-binding protein
CBL_PTK
230:239
DDFDVYSGTP
CBL
0.9997
More...
