DegronMD - P41218(MNDA)

FUNCTION: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

GO - Biological processes (BP): activation of innate immune response [GO:0002218]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to interferon-beta [GO:0035458]; negative regulation of B cell proliferation [GO:0030889... View more >>

GO - Molecular function (MF): double-stranded DNA binding [GO:0003690]

GO - Cellular component (CC): azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S180L	DO46727	PACA	ICGC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.7667
p.S179A	DO222702	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.7588
p.Q177K	SIDM00383	Gastric Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5833
p.Q177K	ACH-002198	Gastric Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5833
p.Q177K	SCH	stomach	COSMIC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5833
p.L175I	TCGA-50-5946	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.3056
p.L175I	DO24556	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.3056
p.P174Q	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.P174Q	ACH-000860	Lung Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.P174Q	NCI-H358	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.P183L	SIDM01006	Plasma Cell Myeloma	GDSC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.P183L	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.P173H	ACH-001414	Bladder Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.H172L	TCGA-D7-A4YT	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2222
p.H172L	DO47723	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2222
p.H172Y	TCGA-ER-A194	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2222
p.H172Y	DO47646	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2222
p.D171Y	TCGA-44-6776	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1944
p.D171Y	DO24060	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1944
p.V170M	TCGA-D6-A6EQ	HNSC	TCGA	PQTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1667

Showing 1 to 20 of 57 entries

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No resistance data available for this Degron.

Kaplan plot for MNDA in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

MNDA

UniProt ID: P41218

Entrez ID: 4332

Protein name: Myeloid cell nuclear differentiation antigen

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for MNDA in