DegronMD

Uniprot ID: P41218

Source protein: Myeloid cell nuclear differentiation antigen

Source gene: MNDA

Class: DEG_SPOP_SBC_1

Location: 176:180

E3 ligase: SPOP

DEGRON score: 0.9954

ASA_SCORE: 100.22

COIL: 0.9638

CONS_SCORE: 0.6781

DSS_SCORE: 0.811

HELIX: 0.017

FCONS_SCORE: 1.5676

RIG_SCORE: 0.5182

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S187L	TCGA-2W-A8YY	CESC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-AJ-A3EL	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-D1-A16Y	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-EE-A29E	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-EE-A2MR	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-EO-A3B0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-FR-A3YO	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-FS-A1ZR	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	TCGA-GN-A8LK	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO223732	CESC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO222753	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO37651	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO37831	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO37819	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO37419	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO51259	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO219773	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO41542	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	DO41524	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	SIDM01588	Endometrial Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S187L	ACH-002508	Skin Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.1389
p.D171Y	TCGA-44-6776	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1944
p.D171Y	DO24060	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.L175I	TCGA-50-5946	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.3056
p.L175I	DO24556	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.3056
p.S167Y	TCGA-55-7995	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0833
p.S167Y	DO45323	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V170M	TCGA-D6-A6EQ	HNSC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1667
p.V170M	DO52085	HNSC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.H172L	TCGA-D7-A4YT	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2222
p.H172L	DO47723	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.P190L	TCGA-EJ-5507	PRAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	TCGA-W5-AA39	CHOL	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	DO51528	PACA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	DO36257	PRAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	SIDM00375	Head and Neck Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	SIDM01577	Plasma Cell Myeloma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P190L	SIDM01752	Pancreatic Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.H172Y	TCGA-ER-A194	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2222
p.H172Y	DO47646	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.V170G	TCGA-IB-7651	PAAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1667
p.V170G	DO46657	PAAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.S179A	DO222702	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7588
p.S180L	DO46727	PACA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7667
p.P183L	SIDM01006	Plasma Cell Myeloma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.25
p.P183L	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.25
p.P174Q	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.P174Q	ACH-000860	Lung Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.2778
p.P174Q	NCI-H358	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.Q177K	SIDM00383	Gastric Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5833
p.Q177K	ACH-002198	Gastric Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.5833
p.Q177K	SCH	stomach	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.5833
p.F188V	SIDM01450	Gastric Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.F188V	ACH-000898	Gastric Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.1111
p.P173H	ACH-001414	Bladder Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with MNDA mutations

All proteins holding degron of PQTSS