DegronMD

Uniprot ID: Q9P2G1

Source protein: Ankyrin repeat and IBR domain-containing protein 1

Source gene: ANKIB1

Class: DEG_SCF_FBW7_1

Location: 288:294

E3 ligase: FBXW7

DEGRON score: 0.8694

ASA_SCORE: 68.7143

COIL: 0.954

CONS_SCORE: 0.391

DSS_SCORE: 0.5933

HELIX: 0.0154

FCONS_SCORE: 0.8496

RIG_SCORE: 0.5875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N279S	TCGA-BR-8487	STAD	TCGA	MPTPPPS	DEG_SCF_FBW7_1	0.0833
p.N279S	DO47867	STAD	ICGC	MPTPPPS	DEG_SCF_FBW7_1	0.0833
p.P293S	TCGA-D1-A160	UCEC	TCGA	MPTPPPS	DEG_SCF_FBW7_1	0.5641
p.P293S	DO41626	UCEC	ICGC	MPTPPPS	DEG_SCF_FBW7_1	0.5641
p.W299C	TCGA-ER-A1A1	SKCM	TCGA	MPTPPPS	DEG_SCF_FBW7_1	0.1944
p.W299C	DO37413	SKCM	ICGC	MPTPPPS	DEG_SCF_FBW7_1	0.1944
p.R283Q	DO230312	COCA	ICGC	MPTPPPS	DEG_SCF_FBW7_1	0.1944
p.L302F	DO222842	COCA	ICGC	MPTPPPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SCF_FBW7_1	288:294	MPTPPPS	FBXW7	0.8694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons