DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SCF_FBW7_1

Location: 1709:1716

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 95.475

COIL: 0.9538

CONS_SCORE: 0.5332

DSS_SCORE: 0.6304

HELIX: 0.0135

FCONS_SCORE: 1.0027

RIG_SCORE: 0.698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1709R	TCGA-85-7697	LUSC	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	0.7512
p.P1709R	DO27053	LUSC	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	0.7512
p.T1710N	TCGA-B5-A11E	UCEC	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	0.5944
p.T1710N	DO41644	UCEC	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	0.5944
p.E1724K	TCGA-BT-A42F	BLCA	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	0.1111
p.E1724K	DO49726	BLCA	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	0.1111
p.T1710S	TCGA-CJ-5679	KIRC	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	0.6005
p.T1710S	DO18184	KIRC	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	0.6005
p.T1705N	DO229015	LICA	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	0.2222
p.A1704P	DO229232	THCA	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	0.1944
p.A1704G	SIDM00105	Ovarian Carcinoma	GDSC	PTTTPTAT	DEG_SCF_FBW7_1	0.1944
p.A1704G	SIDM00093	Ovarian Carcinoma	GDSC	PTTTPTAT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12270	Nucleoprotein TPR	DEG_SCF_FBW7_1	1709:1716	PTTTPTAT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons