DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SPOP_SBC_1

Location: 2244:2248

E3 ligase: SPOP

DEGRON score: 0.5533

ASA_SCORE: 84.94

COIL: 0.6602

CONS_SCORE: 0.524

DSS_SCORE: 0.598

HELIX: 0.0176

FCONS_SCORE: 0.957

RIG_SCORE: 0.7028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2240C	TCGA-17-Z062	LUAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.2222
p.L2251V	TCGA-A5-A0G2	UCEC	TCGA	VTTST	DEG_SPOP_SBC_1	0.25
p.L2251V	DO41235	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	0.25
p.S2247Y	DO228974	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.712
p.P2242T	DO228986	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.2778
p.T2246K	DO229018	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.7306
p.Q2239K	DO229015	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.1944
p.S2234L	DO232224	PBCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.T2254A	SIDM01278	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1667
p.H2236P	SIDM01728	Endometrial Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.H2236P	SIDM01321	Pancreatic Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.H2236P	ACH-000173	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1111
p.H2236P	ACH-000307	Pancreatic Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1111
p.H2236P	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1111
p.T2248A	SIDM01609	Endometrial Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.7139
p.T2248A	ACH-000972	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.7139
p.L2251F	ACH-001610	Brain Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons