DegronMD - A5YKK6(CNOT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T764N	TCGA-85-6561	LUSC	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.3056
p.T764N	DO26518	LUSC	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.3056
p.E1328K	TCGA-B5-A0JY	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1331:1335	Mutation rewiring degron network	0.25
p.G768C	TCGA-BF-A1PZ	SKCM	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.1944
p.G768C	TCGA-GN-A262	SKCM	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.1944
p.G768C	DO37515	SKCM	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.1944
p.G768C	DO50279	SKCM	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.1944
p.E1327G	TCGA-BS-A0UJ	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1331:1335	Mutation rewiring degron network	0.2222
p.A753T	TCGA-CK-4951	COAD	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.25
p.A753T	DO10582	COAD	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.25
p.F766L	TCGA-CV-7435	HNSC	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.25
p.F766L	DO14918	HNSC	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.25
p.T1047N	TCGA-DU-6392	LGG	TCGA	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.25
p.N761K	TCGA-DX-A6Z2	SARC	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.5806
p.N761K	DO220019	SARC	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.5806
p.T764S	TCGA-E7-A541	BLCA	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.3056
p.T764S	DO44037	BLCA	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.3056
p.P755S	TCGA-EE-A29E	SKCM	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.3056
p.P755S	DO37831	SKCM	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.3056
p.S1037R	TCGA-L5-A8NE	ESCA	TCGA	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.25
p.T1041A	TCGA-VS-A94Z	CESC	TCGA	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.6028
p.T1036A	DO51634	CESC	ICGC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.2222
p.A753V	DO233115	GACA	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation rewiring degron network	0.25
p.T1042N	DO22237	LGG	ICGC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.7055
p.T1341N	DO229015	LICA	ICGC	PITTT	DEG_SPOP_SBC_1	1331:1335	Mutation rewiring degron network	0.1667
p.T1053N	DO229037	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation blocking phosphorylation signal	0.5278
p.T1050S	DO26830	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation substituting flanking lysine	0.2778
p.E1323K	DO43041	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1331:1335	Mutation rewiring degron network	0.1111
p.E1322G	DO42745	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1331:1335	Mutation rewiring degron network	0.0833
p.N761S	SIDM00521	Small Cell Lung Carcinoma	GDSC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.5958
p.N761S	COR-L95	lung	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.5958
p.T1045I	SIDM00185	Melanoma	GDSC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.3056
p.T1045I	ACH-002152	Skin Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.3056
p.T1045I	LB2518-MEL	skin	COSMIC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.3056
p.A1030G	SIDM01577	Plasma Cell Myeloma	GDSC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0556
p.A1030G	ACH-000889	Myeloma	CCLE	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0556
p.Q762H	MZ1-PC	pancreas	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.647
p.T763S	MZ1-PC	pancreas	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.6005
p.Q762L	MZ1-PC	pancreas	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	756:763	Mutation altering degron motif	0.6654
p.T1040I	LB2518-MEL	skin	COSMIC	VTTST	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.7078

Kaplan plot for CNOT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNOT1

UniProt ID: A5YKK6

Entrez ID: 23019

Protein name: CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNOT1 in