DegronMD

Uniprot ID: A5YKK6

Source protein: CCR4-NOT transcription complex subunit 1

Source gene: CNOT1

Class: DEG_SCF_FBW7_1

Location: 756:763

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 74.8625

COIL: 0.9218

CONS_SCORE: 0.3057

DSS_SCORE: 0.5514

HELIX: 0.0365

FCONS_SCORE: 1.2194

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T764N	TCGA-85-6561	LUSC	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.3056
p.T764N	DO26518	LUSC	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.3056
p.G768C	TCGA-BF-A1PZ	SKCM	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.1944
p.G768C	TCGA-GN-A262	SKCM	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.1944
p.G768C	DO37515	SKCM	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.1944
p.G768C	DO50279	SKCM	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.1944
p.A753T	TCGA-CK-4951	COAD	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.25
p.A753T	DO10582	COAD	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.25
p.F766L	TCGA-CV-7435	HNSC	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.25
p.F766L	DO14918	HNSC	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.25
p.N761K	TCGA-DX-A6Z2	SARC	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.5806
p.N761K	DO220019	SARC	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.5806
p.T764S	TCGA-E7-A541	BLCA	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.3056
p.T764S	DO44037	BLCA	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.3056
p.P755S	TCGA-EE-A29E	SKCM	TCGA	PLSTPNQT	DEG_SCF_FBW7_1	0.3056
p.P755S	DO37831	SKCM	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.3056
p.A753V	DO233115	GACA	ICGC	PLSTPNQT	DEG_SCF_FBW7_1	0.25
p.N761S	SIDM00521	Small Cell Lung Carcinoma	GDSC	PLSTPNQT	DEG_SCF_FBW7_1	0.5958
p.N761S	COR-L95	lung	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	0.5958
p.Q762H	MZ1-PC	pancreas	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	0.647
p.T763S	MZ1-PC	pancreas	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	0.6005
p.Q762L	MZ1-PC	pancreas	COSMIC	PLSTPNQT	DEG_SCF_FBW7_1	0.6654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SCF_FBW7_1	756:763	PLSTPNQT	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons