DegronMD

Uniprot ID: A5YKK6

Source protein: CCR4-NOT transcription complex subunit 1

Source gene: CNOT1

Class: DEG_SPOP_SBC_1

Location: 1040:1044

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 77.6

COIL: 0.817

CONS_SCORE: 0.25

DSS_SCORE: 0.3324

HELIX: 0.0458

FCONS_SCORE: 1.0218

RIG_SCORE: 0.7507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1047N	TCGA-DU-6392	LGG	TCGA	VTTST	DEG_SPOP_SBC_1	0.25
p.S1037R	TCGA-L5-A8NE	ESCA	TCGA	VTTST	DEG_SPOP_SBC_1	0.25
p.T1041A	TCGA-VS-A94Z	CESC	TCGA	VTTST	DEG_SPOP_SBC_1	0.6028
p.T1036A	DO51634	CESC	ICGC	VTTST	DEG_SPOP_SBC_1	0.2222
p.T1042N	DO22237	LGG	ICGC	VTTST	DEG_SPOP_SBC_1	0.7055
p.T1053N	DO229037	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.5278
p.T1050S	DO26830	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	0.2778
p.T1045I	SIDM00185	Melanoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.3056
p.T1045I	ACH-002152	Skin Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.3056
p.T1045I	LB2518-MEL	skin	COSMIC	VTTST	DEG_SPOP_SBC_1	0.3056
p.A1030G	SIDM01577	Plasma Cell Myeloma	GDSC	VTTST	DEG_SPOP_SBC_1	0.0556
p.A1030G	ACH-000889	Myeloma	CCLE	VTTST	DEG_SPOP_SBC_1	0.0556
p.T1040I	LB2518-MEL	skin	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons