DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VTTST
Uniprot ID:
A5YKK6
Source protein:
CCR4-NOT transcription complex subunit 1
Source gene:
CNOT1
Class:
DEG_SPOP_SBC_1
Location:
1040:1044
E3 ligase:
SPOP
DEGRON score:
0.9972
ASA_SCORE:
77.6
COIL:
0.817
CONS_SCORE:
0.25
DSS_SCORE:
0.3324
HELIX:
0.0458
FCONS_SCORE:
1.0218
RIG_SCORE:
0.7507
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1040I
LB2518-MEL
skin
COSMIC
VTTST
DEG_SPOP_SBC_1
0.7078
p.T1042N
DO22237
LGG
ICGC
VTTST
DEG_SPOP_SBC_1
0.7055
p.T1041A
TCGA-VS-A94Z
CESC
TCGA
VTTST
DEG_SPOP_SBC_1
0.6028
p.T1053N
DO229037
LICA
ICGC
VTTST
DEG_SPOP_SBC_1
0.5278
p.T1045I
SIDM00185
Melanoma
GDSC
VTTST
DEG_SPOP_SBC_1
0.3056
p.T1045I
ACH-002152
Skin Cancer
CCLE
VTTST
DEG_SPOP_SBC_1
0.3056
p.T1045I
LB2518-MEL
skin
COSMIC
VTTST
DEG_SPOP_SBC_1
0.3056
p.T1050S
DO26830
LUSC
ICGC
VTTST
DEG_SPOP_SBC_1
0.2778
p.T1047N
TCGA-DU-6392
LGG
TCGA
VTTST
DEG_SPOP_SBC_1
0.25
p.S1037R
TCGA-L5-A8NE
ESCA
TCGA
VTTST
DEG_SPOP_SBC_1
0.25
p.T1036A
DO51634
CESC
ICGC
VTTST
DEG_SPOP_SBC_1
0.2222
p.A1030G
SIDM01577
Plasma Cell Myeloma
GDSC
VTTST
DEG_SPOP_SBC_1
0.0556
p.A1030G
ACH-000889
Myeloma
CCLE
VTTST
DEG_SPOP_SBC_1
0.0556
Showing 1 to 13 of 13 entries
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Drug responses associated with CNOT1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VTTST
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HAR2
Adhesion G protein-coupled receptor L3
DEG_SPOP_SBC_1
1372:1376
VTTST
SPOP
0.9817
More...
A5YKK6
CCR4-NOT transcription complex subunit 1
DEG_SPOP_SBC_1
1040:1044
VTTST
SPOP
0.9972
More...
O95274
Ly6/PLAUR domain-containing protein 3
DEG_SPOP_SBC_1
255:259
VTTST
SPOP
0.8718
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
4862:4866
VTTST
SPOP
0.9247
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
365:369
VTTST
SPOP
0.9781
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Q685J3
Mucin-17
DEG_SPOP_SBC_1
3430:3434
VTTST
SPOP
0.9177
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Q99102
Mucin-4
DEG_SPOP_SBC_1
266:270
VTTST
SPOP
0.9076
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2256:2260
VTTST
SPOP
0.9908
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3362:3366
VTTST
SPOP
0.9176
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P98088
Mucin-5AC
DEG_SPOP_SBC_1
4093:4097
VTTST
SPOP
0.9149
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P12270
Nucleoprotein TPR
DEG_SPOP_SBC_1
2244:2248
VTTST
SPOP
0.5533
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
1991:1995
VTTST
SPOP
0.8266
More...
Q9ULV0
Unconventional myosin-Vb
DEG_SPOP_SBC_1
950:954
VTTST
SPOP
0.7192
More...
P08670
Vimentin
DEG_SPOP_SBC_1
31:35
VTTST
SPOP
0.9992
More...
Q9H2Y7
Zinc finger protein 106
DEG_SPOP_SBC_1
1396:1400
VTTST
SPOP
0.9451
More...
P15822
Zinc finger protein 40
DEG_SPOP_SBC_1
714:718
VTTST
SPOP
0.6604
More...
Showing 1 to 16 of 16 entries
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