DegronMD - Q9HAR2(ADGRL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1373H	SIDM01951	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation altering degron motif	0.7694
p.A1386V	SIDM00499	Prostate Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.0556
p.A1386V	22RV1	prostate	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.0556
p.H1344D	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.0556
p.H1344D	CAL-12T	lung	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.0556
p.R1348M	SIDM01133	Other Solid Cancers	GDSC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1667
p.R1348M	NCI-H835	lung	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1667
p.R1348S	SIDM01133	Other Solid Cancers	GDSC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1667
p.R1348S	NCI-H835	lung	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1667
p.R1349Q	SIDM01084	Osteosarcoma	GDSC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1944
p.R1349Q	Saos-2	bone	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1944
p.L1366V	NCI-H2081	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1667
p.L1366V	NCI-H2081	lung	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1944
p.E1347G	SK-MEL-31	skin	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1389
p.T1355I	TE-4	oesophagus	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation altering degron motif	0.7078
p.S1344G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.0556
p.S1344G	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.0556
p.N1346K	NCI-H128	lung	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.1111
p.R1382S	NCI-H835	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1667
p.P1371H	ASH-3	thyroid	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.3056
p.P1371H	ASH-3	thyroid	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.0556
p.P1362H	ASH-3	thyroid	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.0556
p.P1362H	ASH-3	thyroid	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.3056
p.H1378D	CAL-12T	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.2778
p.E1372V	SW1271	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation altering degron motif	0.7693
p.E1381V	SW1271	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1944
p.E1373V	SW684	soft tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation altering degron motif	0.7693
p.R1382M	NCI-H835	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1667
p.E1372G	SK-MEL-31	skin	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation altering degron motif	0.7199
p.R1383Q	Saos-2	bone	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1389
p.L1357V	NCI-H2081	lung	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation altering degron motif	0.6765
p.E1356G	SK-MEL-31	skin	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation altering degron motif	0.7199
p.T1364I	TE-4	oesophagus	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1111
p.T1364I	TE-4	oesophagus	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.25
p.E1364V	SW684	soft tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	1372:1376	Mutation rewiring degron network	0.1111
p.E1364V	SW684	soft tissue	COSMIC	DSLYTSMP	CBL_PTK	1354:1361	Mutation rewiring degron network	0.25

Kaplan plot for ADGRL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRL3

UniProt ID: Q9HAR2

Entrez ID: 23284

Protein name: Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRL3 in