DegronMD

Uniprot ID: Q9HAR2

Source protein: Adhesion G protein-coupled receptor L3

Source gene: ADGRL3

Class: CBL_PTK

Location: 1354:1361

E3 ligase: CBL

DEGRON score: 0.8785

ASA_SCORE: 67.2375

COIL: 0.6709

CONS_SCORE: 0.2988

DSS_SCORE: 0.5605

HELIX: 0.254

FCONS_SCORE: 1.0244

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1344D	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	DSLYTSMP	CBL_PTK	0.0556
p.H1344D	CAL-12T	lung	COSMIC	DSLYTSMP	CBL_PTK	0.0556
p.R1348M	SIDM01133	Other Solid Cancers	GDSC	DSLYTSMP	CBL_PTK	0.1667
p.R1348M	NCI-H835	lung	COSMIC	DSLYTSMP	CBL_PTK	0.1667
p.R1348S	SIDM01133	Other Solid Cancers	GDSC	DSLYTSMP	CBL_PTK	0.1667
p.R1348S	NCI-H835	lung	COSMIC	DSLYTSMP	CBL_PTK	0.1667
p.R1349Q	SIDM01084	Osteosarcoma	GDSC	DSLYTSMP	CBL_PTK	0.1944
p.R1349Q	Saos-2	bone	COSMIC	DSLYTSMP	CBL_PTK	0.1944
p.L1366V	NCI-H2081	lung	COSMIC	DSLYTSMP	CBL_PTK	0.1944
p.E1347G	SK-MEL-31	skin	COSMIC	DSLYTSMP	CBL_PTK	0.1389
p.T1355I	TE-4	oesophagus	COSMIC	DSLYTSMP	CBL_PTK	0.7078
p.S1344G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DSLYTSMP	CBL_PTK	0.0556
p.S1344G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSLYTSMP	CBL_PTK	0.0556
p.N1346K	NCI-H128	lung	COSMIC	DSLYTSMP	CBL_PTK	0.1111
p.P1371H	ASH-3	thyroid	COSMIC	DSLYTSMP	CBL_PTK	0.0556
p.P1362H	ASH-3	thyroid	COSMIC	DSLYTSMP	CBL_PTK	0.3056
p.L1357V	NCI-H2081	lung	COSMIC	DSLYTSMP	CBL_PTK	0.6765
p.E1356G	SK-MEL-31	skin	COSMIC	DSLYTSMP	CBL_PTK	0.7199
p.T1364I	TE-4	oesophagus	COSMIC	DSLYTSMP	CBL_PTK	0.25
p.E1364V	SW684	soft_tissue	COSMIC	DSLYTSMP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAR2	Adhesion G protein-coupled receptor L3	CBL_PTK	1354:1361	DSLYTSMP	CBL	0.8785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons