DegronMD

Uniprot ID: Q9HAR2

Source protein: Adhesion G protein-coupled receptor L3

Source gene: ADGRL3

Class: DEG_SPOP_SBC_1

Location: 1372:1376

E3 ligase: SPOP

DEGRON score: 0.9817

ASA_SCORE: 83.2

COIL: 0.919

CONS_SCORE: 0.26

DSS_SCORE: 0.6288

HELIX: 0.0692

FCONS_SCORE: 0.9078

RIG_SCORE: 0.685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1373H	SIDM01951	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.7694
p.A1386V	SIDM00499	Prostate Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.0556
p.A1386V	22RV1	prostate	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0556
p.L1366V	NCI-H2081	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1667
p.R1382S	NCI-H835	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1667
p.P1371H	ASH-3	thyroid	COSMIC	VTTST	DEG_SPOP_SBC_1	0.3056
p.P1362H	ASH-3	thyroid	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0556
p.H1378D	CAL-12T	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.2778
p.E1372V	SW1271	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7693
p.E1381V	SW1271	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1944
p.E1373V	SW684	soft_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7693
p.R1382M	NCI-H835	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1667
p.E1372G	SK-MEL-31	skin	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7199
p.R1383Q	Saos-2	bone	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1389
p.T1364I	TE-4	oesophagus	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1111
p.E1364V	SW684	soft_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons