DegronMD

Uniprot ID: Q9H2Y7

Source protein: Zinc finger protein 106

Source gene: ZNF106

Class: DEG_SPOP_SBC_1

Location: 1396:1400

E3 ligase: SPOP

DEGRON score: 0.9451

ASA_SCORE: 45.82

COIL: 0.4148

CONS_SCORE: 0.4181

DSS_SCORE: 0.5174

HELIX: 0.006

FCONS_SCORE: 1.1711

RIG_SCORE: 0.7399

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1398I	TCGA-AA-A02R	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.8189
p.R1405M	TCGA-AZ-4315	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.1944
p.A1387D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	0.0833
p.A1387D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	0.0833
p.A1387D	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...

Showing 1 to 16 of 16 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons