DegronMD

Uniprot ID: Q99102

Source protein: Mucin-4

Source gene: MUC4

Class: DEG_SPOP_SBC_1

Location: 266:270

E3 ligase: SPOP

DEGRON score: 0.9076

ASA_SCORE: 89.06

COIL: 0.8884

CONS_SCORE: 0.3071

DSS_SCORE: 0.5728

HELIX: 0.012

FCONS_SCORE: 0.9447

RIG_SCORE: 0.7508

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T256I	TCGA-19-5956	GBM	TCGA	VTTST	DEG_SPOP_SBC_1	0.0556
p.T256I	DO13863	GBM	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.E279K	TCGA-86-7711	LUAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.0833
p.E279K	TCGA-EE-A3AG	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.0833
p.E279K	TCGA-FS-A1ZK	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.0833
p.E279K	DO25717	LUAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.E279K	DO37474	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.E279K	DO37471	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.S272T	TCGA-A6-3809	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.7222
p.S272T	DO8722	COAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.7222
p.S272C	TCGA-C5-A905	CESC	TCGA	VTTST	DEG_SPOP_SBC_1	0.7222
p.S272C	DO49918	CESC	ICGC	VTTST	DEG_SPOP_SBC_1	0.7222
p.G271C	TCGA-CM-6171	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.3056
p.G271C	DO8151	COAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.G275E	TCGA-ER-A193	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.1944
p.G275E	DO47368	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.1944
p.S261L	TCGA-FD-A43X	BLCA	TCGA	VTTST	DEG_SPOP_SBC_1	0.1944
p.S261L	DO44067	BLCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.1944
p.T265P	TCGA-MV-A51V	BLCA	TCGA	VTTST	DEG_SPOP_SBC_1	0.3056
p.T265P	DO474	BLCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.L274V	TCGA-RA-A741	CESC	TCGA	VTTST	DEG_SPOP_SBC_1	0.2222
p.L274V	DO49013	CESC	ICGC	VTTST	DEG_SPOP_SBC_1	0.2222
p.E273K	DO8119	COAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.25
p.N266K	DO230334	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO229010	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO229013	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO229016	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO229003	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO229005	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO229346	LAML	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.N266K	DO231160	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	0.6918
p.T280A	DO50770	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.G265V	DO232852	NACA	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.P267Q	DO233297	NACA	ICGC	VTTST	DEG_SPOP_SBC_1	0.7035
p.T273A	DO229502	SKCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.25
p.Q257K	DO37778	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.P267T	DO37703	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.7031
p.E280K	DO37430	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.F272V	DO47767	STAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.7222
p.E266K	DO43907	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	0.7022
p.P277S	SIDM01175	Other Sarcomas	GDSC	VTTST	DEG_SPOP_SBC_1	0.1389
p.P277S	ACH-002309	Sarcoma	CCLE	VTTST	DEG_SPOP_SBC_1	0.1389
p.P277S	SW684	soft_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1389
p.V266M	SIDM00282	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.7208
p.V266M	ACH-000998	Colon/Colorectal Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.7208
p.V266M	CW-2	large_intestine	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7208
p.T267K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.6195
p.T267K	H513	pleura	COSMIC	VTTST	DEG_SPOP_SBC_1	0.6195
p.F279Y	ACH-000004	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279Y	ACH-000005	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279Y	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279Y	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279I	ACH-000004	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279I	ACH-000005	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279I	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0833
p.F279I	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.0833
p.Y278C	ACH-000213	Pancreatic Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1111
p.Y278C	HuP-T4	pancreas	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1111
p.V260A	ACH-000999	Colon/Colorectal Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1667
p.V260A	SNU-1040	large_intestine	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1667
p.R263H	ACH-001350	Thyroid Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.3611
p.R263H	HTC-C3	thyroid	COSMIC	VTTST	DEG_SPOP_SBC_1	0.3611
p.R264W	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.2778
p.R271H	HDQ-P1	breast	COSMIC	VTTST	DEG_SPOP_SBC_1	0.3056
p.L272F	NCI-H196	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTST

Degron related mutations and impact score

Drug responses associated with MUC4 mutations

All proteins holding degron of VTTST