DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 4862:4866

E3 ligase: SPOP

DEGRON score: 0.9247

ASA_SCORE: 85.38

COIL: 0.8228

CONS_SCORE: 0

DSS_SCORE: 0.6018

HELIX: 0.0244

FCONS_SCORE: 0

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M4867I	TCGA-A5-A2K5	UCEC	TCGA	VTTST	DEG_SPOP_SBC_1	0.3056
p.M4867I	TCGA-FW-A5DY	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.3056
p.M4867I	DO223076	ESCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.M4867I	DO47257	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.M4867I	DO41379	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.I4872N	TCGA-AA-A010	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.1667
p.E4868K	TCGA-D3-A5GU	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.2778
p.E4868K	TCGA-EE-A3AE	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.2778
p.E4868K	DO37802	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.2778
p.E4868K	DO47584	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.2778
p.S4875L	TCGA-FI-A2D5	UCEC	TCGA	VTTST	DEG_SPOP_SBC_1	0.5278
p.S4875L	DO41331	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	0.5278
p.N4861I	DO233166	GACA	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.P4854Q	DO231179	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	0.1111
p.P4860S	DO220885	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	0.2778
p.S4873F	DO222653	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	0.1389
p.S4873F	DO229446	SKCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.1389
p.P4852S	DO222880	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.T4858A	SIDM01126	Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.2222
p.T4858A	ACH-001599	Lung Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.T4858A	NCI-H64	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons