DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3430:3434

E3 ligase: SPOP

DEGRON score: 0.9177

ASA_SCORE: 84.6

COIL: 0.7714

CONS_SCORE: 0.6451

DSS_SCORE: 0.58

HELIX: 0.015

FCONS_SCORE: 1.12

RIG_SCORE: 0.7506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3443V	TCGA-91-6831	LUAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.0833
p.A3443V	DO23753	LUAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.P3423H	TCGA-D7-A4YV	STAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.1389
p.P3423H	DO47777	STAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.1389
p.T3431I	TCGA-ED-A7PZ	LIHC	TCGA	VTTST	DEG_SPOP_SBC_1	0.5966
p.T3431I	DO48532	LIHC	ICGC	VTTST	DEG_SPOP_SBC_1	0.5966
p.D3425N	TCGA-GN-A263	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.1944
p.D3425N	DO37766	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.1944
p.S3438L	TCGA-GN-A26C	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.2222
p.S3438L	DO37782	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.2222
p.P3440S	TCGA-GN-A26C	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.1667
p.P3440S	DO37782	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	0.1667
p.S3438T	TCGA-UY-A78K	BLCA	TCGA	VTTST	DEG_SPOP_SBC_1	0.2222
p.S3438T	DO219031	BLCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.2222
p.T3421I	TCGA-WN-A9G9	KIRP	TCGA	VTTST	DEG_SPOP_SBC_1	0.0833
p.T3421I	DO51569	KIRP	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.E3435K	DO225391	BRCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.L3429P	DO228944	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	0.3056
p.S3420L	DO222653	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.P3423S	DO218847	SKCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.1389
p.T3441A	SIDM00290	Gastric Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1389
p.T3441A	ACH-000847	Gastric Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1389
p.T3441A	HGC-27	stomach	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1389
p.T3428N	SIDM01611	Endometrial Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.2778
p.T3428N	ACH-000996	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.2778
p.D3425G	ACH-001664	Gastric Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons