DegronMD

Uniprot ID: Q9ULV0

Source protein: Unconventional myosin-Vb

Source gene: MYO5B

Class: DEG_SPOP_SBC_1

Location: 950:954

E3 ligase: SPOP

DEGRON score: 0.7192

ASA_SCORE: 77.46

COIL: 0.5728

CONS_SCORE: 0.2397

DSS_SCORE: 0.332

HELIX: 0.4038

FCONS_SCORE: 0.6859

RIG_SCORE: 0.766

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M957I	TCGA-49-6744	LUAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.25
p.E958K	TCGA-61-2113	OV	TCGA	VTTST	DEG_SPOP_SBC_1	0.2222
p.R961W	TCGA-EJ-A7NG	PRAD	TCGA	VTTST	DEG_SPOP_SBC_1	0.1389
p.R961W	SIDM00301	Pancreatic Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1389
p.R961W	KP-4	pancreas	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1389
p.V959I	TCGA-ER-A2NC	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.1944
p.V959I	SIDM00338	Acute Myeloid Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	0.1944
p.V959I	ACH-000439	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.1944
p.V959I	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1944
p.S949Y	TCGA-GN-A266	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	0.75
p.S948A	DO3055	BRCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.2778
p.S943Y	DO8264	COAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.5833
p.S943Y	DO41235	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	0.5833
p.A953V	DO232761	PBCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.6936
p.K942R	SIDM00535	Chondrosarcoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	SIDM01473	Plasma Cell Myeloma	GDSC	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-000438	Lung Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-000541	Myeloma	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-001184	Sarcoma	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-001515	Cervical Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-001519	Bone Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-002059	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.K942R	ACH-002800	Unknown	CCLE	VTTST	DEG_SPOP_SBC_1	0.2222
p.E960K	SIDM00263	Ewing's Sarcoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1667
p.E960K	ACH-002106	Bone Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1667
p.E960K	ES5	bone	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1667
p.V950M	SIDM00839	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.7208
p.V950M	LoVo	large_intestine	COSMIC	VTTST	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTST

Degron related mutations and impact score

Drug responses associated with MYO5B mutations

All proteins holding degron of VTTST