MYO5B
UniProt ID: Q9ULV0
Entrez ID: 4645
Protein name: Unconventional myosin-Vb
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. T...
FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}.
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GO - Biological processes (BP):
actin filament organization [GO:0007015]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; renal water homeostasis [GO:0003091]; vesicle-mediated transport [GO:0016192]; vesicle transport along actin filament [GO:0030050]...
actin filament organization [GO:0007015]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; renal water homeostasis [GO:0003091]; vesicle-mediated transport [GO:0016192]; vesicle transport along actin filament [GO:0030050]
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GO - Molecular function (MF):
actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; small GTPase binding [GO:0031267]...
actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]...
actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; vesicle [GO:0031982]
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MYO5B
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Kaplan plot for MYO5B in
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*NOTE: the Kaplan plots were collected from OncoLnc