DegronMD

Uniprot ID: O95274

Source protein: Ly6/PLAUR domain-containing protein 3

Source gene: LYPD3

Class: DEG_SPOP_SBC_1

Location: 255:259

E3 ligase: SPOP

DEGRON score: 0.8718

ASA_SCORE: 97.56

COIL: 0.9216

CONS_SCORE: 0.6787

DSS_SCORE: 0.6466

HELIX: 0.0144

FCONS_SCORE: 1.0667

RIG_SCORE: 0.6433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T256I	TCGA-D6-6515	HNSC	TCGA	VTTST	DEG_SPOP_SBC_1	0.5966
p.T256I	DO14206	HNSC	ICGC	VTTST	DEG_SPOP_SBC_1	0.5966
p.T256I	DO42673	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	0.5966
p.T247M	DO234312	ESAD	ICGC	VTTST	DEG_SPOP_SBC_1	0.1111
p.S260L	SIDM02022	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.3056
p.T247K	SIDM00773	Non-Cancerous	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00654	Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00690	Head and Neck Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00878	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00971	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00309	Mesothelioma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM01159	Other Sarcomas	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00793	Burkitt's Lymphoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00954	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00808	Burkitt's Lymphoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM00628	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111
p.T247K	SIDM01254	Burkitt's Lymphoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons