DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SCF_FBW7_1

Location: 1862:1867

E3 ligase: FBXW7

DEGRON score: 0.9346

ASA_SCORE: 85.25

COIL: 0.9272

CONS_SCORE: 0.4948

DSS_SCORE: 0.5747

HELIX: 0.0258

FCONS_SCORE: 0.9564

RIG_SCORE: 0.6837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1855V	TCGA-92-8065	LUSC	TCGA	VTPVGT	DEG_SCF_FBW7_1	0.1389
p.L1855V	DO27074	LUSC	ICGC	VTPVGT	DEG_SCF_FBW7_1	0.1389
p.K1857T	TCGA-VQ-A8PO	STAD	TCGA	VTPVGT	DEG_SCF_FBW7_1	0.3056
p.K1857T	DO51773	STAD	ICGC	VTPVGT	DEG_SCF_FBW7_1	0.3056
p.E1875K	DO227807	COCA	ICGC	VTPVGT	DEG_SCF_FBW7_1	0.1111
p.A1873E	DO229038	LICA	ICGC	VTPVGT	DEG_SCF_FBW7_1	0.1667
p.K1858N	SIDM01299	Colorectal Carcinoma	GDSC	VTPVGT	DEG_SCF_FBW7_1	0.3333
p.M1872V	SIDM01113	Other Sarcomas	GDSC	VTPVGT	DEG_SCF_FBW7_1	0.1944
p.M1872V	SK-UT-1	soft_tissue	COSMIC	VTPVGT	DEG_SCF_FBW7_1	0.1944
p.S1861I	ACH-001377	Pancreatic Cancer	CCLE	VTPVGT	DEG_SCF_FBW7_1	0.3056
p.K1857R	ACH-001786	Colon/Colorectal Cancer	CCLE	VTPVGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12270	Nucleoprotein TPR	DEG_SCF_FBW7_1	1862:1867	VTPVGT	FBXW7	0.9346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons