DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SCF_FBW7_1

Location: 1819:1826

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 86.3

COIL: 0.9273

CONS_SCORE: 0.5168

DSS_SCORE: 0.5715

HELIX: 0.0178

FCONS_SCORE: 0.996

RIG_SCORE: 0.6418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1820L	TCGA-AN-A046	BRCA	TCGA	VSATPSSS	DEG_SCF_FBW7_1	0.6556
p.S1820L	DO1285	BRCA	ICGC	VSATPSSS	DEG_SCF_FBW7_1	0.6556
p.S1820L	SIDM01611	Endometrial Carcinoma	GDSC	VSATPSSS	DEG_SCF_FBW7_1	0.6556
p.S1820L	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.6556
p.V1815A	TCGA-AP-A0LP	UCEC	TCGA	VSATPSSS	DEG_SCF_FBW7_1	0.2222
p.V1815A	DO43146	UCEC	ICGC	VSATPSSS	DEG_SCF_FBW7_1	0.2222
p.R1830H	TCGA-D1-A167	UCEC	TCGA	VSATPSSS	DEG_SCF_FBW7_1	0.2222
p.R1830H	DO40978	UCEC	ICGC	VSATPSSS	DEG_SCF_FBW7_1	0.2222
p.T1831K	DO229022	LICA	ICGC	VSATPSSS	DEG_SCF_FBW7_1	0.6389
p.S1824N	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VSATPSSS	DEG_SCF_FBW7_1	0.5958
p.S1824N	ACH-000785	Lung Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.5958
p.S1824N	NCI-H2126	lung	COSMIC	VSATPSSS	DEG_SCF_FBW7_1	0.5958
p.S1824G	SIDM00677	Colorectal Carcinoma	GDSC	VSATPSSS	DEG_SCF_FBW7_1	0.5882
p.S1824G	ACH-000007	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.5882
p.S1824G	LS-513	large_intestine	COSMIC	VSATPSSS	DEG_SCF_FBW7_1	0.5882
p.T1822N	ACH-000008	Skin Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.8166
p.T1822N	ACH-000202	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.8166
p.T1822N	ACH-000219	Skin Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.8166
p.T1822N	ACH-000491	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.8166
p.T1822N	ACH-000565	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.8166
p.T1822N	ACH-002173	Lung Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	0.8166

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12270	Nucleoprotein TPR	DEG_SCF_FBW7_1	1819:1826	VSATPSSS	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons