DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SPOP_SBC_1

Location: 1748:1752

E3 ligase: SPOP

DEGRON score: 0.8843

ASA_SCORE: 98.72

COIL: 0.9096

CONS_SCORE: 0.3886

DSS_SCORE: 0.6043

HELIX: 0.0192

FCONS_SCORE: 0.7651

RIG_SCORE: 0.6208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1749C	TCGA-AP-A0LM	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	TCGA-AP-A1DV	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	TCGA-D1-A17Q	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	TCGA-D3-A8GM	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	DO50288	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	DO43306	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	DO43186	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	DO41903	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	SIDM01043	Other Sarcomas	GDSC	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	ACH-000913	Endometrial/Uterine Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.719
p.R1749C	ESS-1	endometrium	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.719
p.S1760Y	TCGA-DF-A2KU	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.1111
p.S1760Y	DO223286	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1111
p.P1753S	TCGA-DF-A2KU	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.3056
p.P1753S	DO223286	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.S1745G	TCGA-UF-A7JA	HNSC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.25
p.S1745G	DO52112	HNSC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.25
p.R1749H	DO233652	GACA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7133
p.R1749H	DO229075	PRAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7133
p.R1749H	DO229459	SKCA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7133
p.S1743R	DO229037	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1944
p.S1758F	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.S1758F	ACH-000841	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.1667
p.S1758F	NCI-H2087	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.V1748I	SIDM00151	Ovarian Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.7076
p.R1749S	SIDM00850	Gastric Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.6316
p.R1749S	ACH-000880	Gastric Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.6316
p.R1749S	AGS	stomach	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.6316
p.I1759V	ACH-000829	Myeloma	CCLE	VRSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60941	Dystrobrevin beta	DEG_SPOP_SBC_1	548:552	VRSTS	SPOP	0.7802	More...
O95696	Bromodomain-containing protein 1	DEG_SPOP_SBC_1	420:424	VRSTS	SPOP	0.9741	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1748:1752	VRSTS	SPOP	0.8843	More...
Q7Z6J6	FERM domain-containing protein 5	DEG_SPOP_SBC_1	392:396	VRSTS	SPOP	0.8657	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	569:573	VRSTS	SPOP	0.9813	More...
Q5VZP5	Serine/threonine/tyrosine-interacting-like protein 2	DEG_SPOP_SBC_1	1001:1005	VRSTS	SPOP	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRSTS

Degron related mutations and impact score

Drug responses associated with TPR mutations

All proteins holding degron of VRSTS