DegronMD

Uniprot ID: O60941

Source protein: Dystrobrevin beta

Source gene: DTNB

Class: DEG_SPOP_SBC_1

Location: 548:552

E3 ligase: SPOP

DEGRON score: 0.7802

ASA_SCORE: 86.96

COIL: 0.8646

CONS_SCORE: 0.349

DSS_SCORE: 0.7871

HELIX: 0.0354

FCONS_SCORE: 0.8495

RIG_SCORE: 0.6006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G541S	TCGA-A6-6781	COAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.1389
p.G541S	DO8447	COAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1389
p.S552P	TCGA-AN-A0FY	BRCA	TCGA	VRSTS	DEG_SPOP_SBC_1	0.7863
p.S552P	DO2108	BRCA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7863
p.S552P	ACH-001410	Bladder Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.7863
p.G541C	TCGA-EE-A20F	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	0.1389
p.R542Q	TCGA-HF-7132	STAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.1667
p.R542Q	DO38214	STAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.V542M	DO222397	BTCA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.E558D	DO222616	ESCA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.A553E	DO229045	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.E550G	DO44978	LIHC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7199
p.E551K	DO25867	LUAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7022
p.A547T	DO41746	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.N560S	DO41331	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1111
p.P543A	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.1944
p.P543A	ACH-000860	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.1944
p.T558P	ACH-002371	Non-Cancerous	CCLE	VRSTS	DEG_SPOP_SBC_1	0.1667
p.T549P	H3255	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.7031
p.T549P	CAKI-1	kidney	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.7031
p.V539M	NCI-H727	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.0833
p.T556P	H3255	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.6667
p.T556P	CAKI-1	kidney	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.6667
p.R559K	NCI-H2087	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60941	Dystrobrevin beta	DEG_SPOP_SBC_1	548:552	VRSTS	SPOP	0.7802	More...
O95696	Bromodomain-containing protein 1	DEG_SPOP_SBC_1	420:424	VRSTS	SPOP	0.9741	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1748:1752	VRSTS	SPOP	0.8843	More...
Q7Z6J6	FERM domain-containing protein 5	DEG_SPOP_SBC_1	392:396	VRSTS	SPOP	0.8657	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	569:573	VRSTS	SPOP	0.9813	More...
Q5VZP5	Serine/threonine/tyrosine-interacting-like protein 2	DEG_SPOP_SBC_1	1001:1005	VRSTS	SPOP	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons