DegronMD - Q5VZP5(STYXL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1008L	TCGA-55-7994	LUAD	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.25
p.S1008L	DO45311	LUAD	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.25
p.F1007L	TCGA-AX-A05Z	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.F1007L	TCGA-EO-A22R	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.F1007L	DO40884	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.F1007L	DO42713	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.N999K	TCGA-D6-A74Q	HNSC	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.N999K	DO52087	HNSC	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.E1014K	TCGA-EB-A3XF	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0833
p.E1014K	DO37437	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0833
p.E1014K	ACH-002309	Sarcoma	CCLE	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0833
p.E1014K	SW684	soft tissue	COSMIC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0833
p.G998S	TCGA-IB-7651	PAAD	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.25
p.G998S	DO46657	PAAD	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.25
p.E995Q	TCGA-JW-A5VL	CESC	TCGA	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.1667
p.E995Q	DO49976	CESC	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.1667
p.R1006W	DO48200	ESCA	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.3056
p.S1003I	DO229032	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation altering degron motif	0.7341
p.G1015C	DO229045	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0556
p.S1000F	DO220841	MELA	ICGC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.3056
p.R1006Q	ACH-002171	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.3056
p.R1006Q	NCI-H250	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.3056

Kaplan plot for STYXL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STYXL2

UniProt ID: Q5VZP5

Entrez ID: 92235

Protein name: Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STYXL2 in