DegronMD

Uniprot ID: Q5VZP5

Source protein: Serine/threonine/tyrosine-interacting-like protein 2

Source gene: STYXL2

Class: DEG_SPOP_SBC_1

Location: 1001:1005

E3 ligase: SPOP

DEGRON score: 0.8835

ASA_SCORE: 71.46

COIL: 0.5044

CONS_SCORE: 0.4098

DSS_SCORE: 0.6016

HELIX: 0.145

FCONS_SCORE: 1.0547

RIG_SCORE: 0.6298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1008L	TCGA-55-7994	LUAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.25
p.S1008L	DO45311	LUAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.25
p.F1007L	TCGA-AX-A05Z	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.2778
p.F1007L	TCGA-EO-A22R	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.2778
p.F1007L	DO40884	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.2778
p.F1007L	DO42713	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.2778
p.N999K	TCGA-D6-A74Q	HNSC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.2778
p.N999K	DO52087	HNSC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.2778
p.E1014K	TCGA-EB-A3XF	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	0.0833
p.E1014K	DO37437	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	0.0833
p.E1014K	ACH-002309	Sarcoma	CCLE	VRSTS	DEG_SPOP_SBC_1	0.0833
p.E1014K	SW684	soft_tissue	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.0833
p.G998S	TCGA-IB-7651	PAAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.25
p.G998S	DO46657	PAAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.25
p.E995Q	TCGA-JW-A5VL	CESC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.1667
p.E995Q	DO49976	CESC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.R1006W	DO48200	ESCA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.S1003I	DO229032	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7341
p.G1015C	DO229045	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.0556
p.S1000F	DO220841	MELA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.R1006Q	ACH-002171	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.3056
p.R1006Q	NCI-H250	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60941	Dystrobrevin beta	DEG_SPOP_SBC_1	548:552	VRSTS	SPOP	0.7802	More...
O95696	Bromodomain-containing protein 1	DEG_SPOP_SBC_1	420:424	VRSTS	SPOP	0.9741	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1748:1752	VRSTS	SPOP	0.8843	More...
Q7Z6J6	FERM domain-containing protein 5	DEG_SPOP_SBC_1	392:396	VRSTS	SPOP	0.8657	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	569:573	VRSTS	SPOP	0.9813	More...
Q5VZP5	Serine/threonine/tyrosine-interacting-like protein 2	DEG_SPOP_SBC_1	1001:1005	VRSTS	SPOP	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons