DegronMD

Uniprot ID: Q9P202

Source protein: Whirlin

Source gene: WHRN

Class: DEG_SPOP_SBC_1

Location: 569:573

E3 ligase: SPOP

DEGRON score: 0.9813

ASA_SCORE: 76.42

COIL: 0.7908

CONS_SCORE: 0.4059

DSS_SCORE: 0.5313

HELIX: 0.1414

FCONS_SCORE: 0.9054

RIG_SCORE: 0.6896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A560T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VRSTS	DEG_SPOP_SBC_1	0.0833
p.G575E	SIDM01228	Melanoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.2778
p.G575E	CHL-1	skin	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60941	Dystrobrevin beta	DEG_SPOP_SBC_1	548:552	VRSTS	SPOP	0.7802	More...
O95696	Bromodomain-containing protein 1	DEG_SPOP_SBC_1	420:424	VRSTS	SPOP	0.9741	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1748:1752	VRSTS	SPOP	0.8843	More...
Q7Z6J6	FERM domain-containing protein 5	DEG_SPOP_SBC_1	392:396	VRSTS	SPOP	0.8657	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	569:573	VRSTS	SPOP	0.9813	More...
Q5VZP5	Serine/threonine/tyrosine-interacting-like protein 2	DEG_SPOP_SBC_1	1001:1005	VRSTS	SPOP	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons