DegronMD - O60941(DTNB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K359N	TCGA-91-6830	LUAD	TCGA	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.2778
p.K359N	DO25867	LUAD	ICGC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.2778
p.G541S	TCGA-A6-6781	COAD	TCGA	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.G541S	DO8447	COAD	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.S552P	TCGA-AN-A0FY	BRCA	TCGA	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7863
p.S552P	DO2108	BRCA	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7863
p.S552P	ACH-001410	Bladder Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7863
p.M350V	TCGA-CC-A5UD	LIHC	TCGA	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.6097
p.M350V	DO219552	LIHC	ICGC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.6097
p.M342I	TCGA-DK-A1AC	BLCA	TCGA	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.1667
p.M342I	DO514	BLCA	ICGC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.1667
p.G541C	TCGA-EE-A20F	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.R542Q	TCGA-HF-7132	STAD	TCGA	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.R542Q	DO38214	STAD	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.V542M	DO222397	BTCA	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.E558D	DO222616	ESCA	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.A553E	DO229045	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.E550G	DO44978	LIHC	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7199
p.E551K	DO25867	LUAD	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7022
p.R367Q	DO41020	UCEC	ICGC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.0556
p.A547T	DO41746	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.N560S	DO41331	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.D366N	SIDM00422	Hodgkin's Lymphoma	GDSC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.0833
p.D366N	ACH-001203	Lymphoma	CCLE	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.0833
p.D366N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.0833
p.M346V	SIDM00845	Burkitt's Lymphoma	GDSC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.2778
p.M346V	SIDM01519	Head and Neck Carcinoma	GDSC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.2778
p.M346V	ACH-000786	Lymphoma	CCLE	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.2778
p.P543A	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.P543A	ACH-000860	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S351P	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.6752
p.S351P	ACH-000747	Lung Cancer	CCLE	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.6752
p.S351P	NCI-H1703	lung	COSMIC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.6752
p.S348N	SIDM01617	Endometrial Carcinoma	GDSC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.7069
p.S348N	ACH-000994	Endometrial/Uterine Cancer	CCLE	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation altering degron motif	0.7069
p.T558P	ACH-002371	Non-Cancerous	CCLE	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.T549P	H3255	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7031
p.T549P	CAKI-1	kidney	COSMIC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7031
p.V539M	NCI-H727	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.T556P	H3255	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation blocking phosphorylation signal	0.6667
p.T556P	CAKI-1	kidney	COSMIC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation blocking phosphorylation signal	0.6667
p.P366L	MCC13	skin	COSMIC	SHMSSGVPTP	DEG_COP1_1	348:357	Mutation rewiring degron network	0.0833
p.R559K	NCI-H2087	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389

Kaplan plot for DTNB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DTNB

UniProt ID: O60941

Entrez ID: 1838

Protein name: Dystrobrevin beta (DTN-B) (Beta-dystrobrevin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DTNB in