DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SHMSSGVPTP
Uniprot ID:
O60941
Source protein:
Dystrobrevin beta
Source gene:
DTNB
Class:
DEG_COP1_1
Location:
348:357
E3 ligase:
COP1
DEGRON score:
0.9912
ASA_SCORE:
65.29
COIL:
0.824
CONS_SCORE:
0.3068
DSS_SCORE:
0.5793
HELIX:
0.0677
FCONS_SCORE:
1.049
RIG_SCORE:
0.6477
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K359N
TCGA-91-6830
LUAD
TCGA
SHMSSGVPTP
DEG_COP1_1
0.2778
p.K359N
DO25867
LUAD
ICGC
SHMSSGVPTP
DEG_COP1_1
0.2778
p.M350V
TCGA-CC-A5UD
LIHC
TCGA
SHMSSGVPTP
DEG_COP1_1
0.6097
p.M350V
DO219552
LIHC
ICGC
SHMSSGVPTP
DEG_COP1_1
0.6097
p.M342I
TCGA-DK-A1AC
BLCA
TCGA
SHMSSGVPTP
DEG_COP1_1
0.1667
p.M342I
DO514
BLCA
ICGC
SHMSSGVPTP
DEG_COP1_1
0.1667
p.R367Q
DO41020
UCEC
ICGC
SHMSSGVPTP
DEG_COP1_1
0.0556
p.D366N
SIDM00422
Hodgkin's Lymphoma
GDSC
SHMSSGVPTP
DEG_COP1_1
0.0833
p.D366N
ACH-001203
Lymphoma
CCLE
SHMSSGVPTP
DEG_COP1_1
0.0833
p.D366N
SUP-HD1
haematopoietic_and_lymphoid_tissue
COSMIC
SHMSSGVPTP
DEG_COP1_1
0.0833
p.M346V
SIDM00845
Burkitt's Lymphoma
GDSC
SHMSSGVPTP
DEG_COP1_1
0.2778
p.M346V
SIDM01519
Head and Neck Carcinoma
GDSC
SHMSSGVPTP
DEG_COP1_1
0.2778
p.M346V
ACH-000786
Lymphoma
CCLE
SHMSSGVPTP
DEG_COP1_1
0.2778
p.S351P
SIDM00740
Squamous Cell Lung Carcinoma
GDSC
SHMSSGVPTP
DEG_COP1_1
0.6752
p.S351P
ACH-000747
Lung Cancer
CCLE
SHMSSGVPTP
DEG_COP1_1
0.6752
p.S351P
NCI-H1703
lung
COSMIC
SHMSSGVPTP
DEG_COP1_1
0.6752
p.S348N
SIDM01617
Endometrial Carcinoma
GDSC
SHMSSGVPTP
DEG_COP1_1
0.7069
p.S348N
ACH-000994
Endometrial/Uterine Cancer
CCLE
SHMSSGVPTP
DEG_COP1_1
0.7069
p.P366L
MCC13
skin
COSMIC
SHMSSGVPTP
DEG_COP1_1
0.0833
Drug responses associated with DTNB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SHMSSGVPTP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60941
Dystrobrevin beta
DEG_COP1_1
348:357
SHMSSGVPTP
COP1
0.9912
More...