DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: LIG_APCC_ABBA_1

Location: 2222:2227

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7634

ASA_SCORE: 98.0167

COIL: 0.8773

CONS_SCORE: 0.4971

DSS_SCORE: 0.5009

HELIX: 0.0678

FCONS_SCORE: 0.9516

RIG_SCORE: 0.7866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2232Y	TCGA-44-7670	LUAD	TCGA	VTVFTE	LIG_APCC_ABBA_1	0.1944
p.D2232Y	DO23555	LUAD	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.1944
p.V2222M	TCGA-A8-A06R	BRCA	TCGA	VTVFTE	LIG_APCC_ABBA_1	0.6097
p.V2222M	DO5165	BRCA	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.6097
p.T2229A	TCGA-BR-6452	STAD	TCGA	VTVFTE	LIG_APCC_ABBA_1	0.2778
p.T2229A	DO38404	STAD	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.2778
p.T2223A	TCGA-EO-A22R	UCEC	TCGA	VTVFTE	LIG_APCC_ABBA_1	0.6028
p.T2223A	DO42713	UCEC	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.6028
p.P2212L	DO49684	LIAD	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.0556
p.T2213S	DO48719	LIRI	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.0833
p.S2234L	DO232224	PBCA	ICGC	VTVFTE	LIG_APCC_ABBA_1	0.1389
p.S2228R	SIDM00662	Melanoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	0.3056
p.S2228R	ACH-000135	Non-Cancerous	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.3056
p.S2228R	Hs940-T	skin	COSMIC	VTVFTE	LIG_APCC_ABBA_1	0.3056
p.T2229N	SIDM00241	Breast Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	0.2778
p.T2229N	ACH-002179	Breast Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.2778
p.T2229N	OCUB-M	breast	COSMIC	VTVFTE	LIG_APCC_ABBA_1	0.2778
p.H2236P	SIDM01728	Endometrial Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	0.0833
p.H2236P	SIDM01321	Pancreatic Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	0.0833
p.H2236P	ACH-000173	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.0833
p.H2236P	ACH-000307	Pancreatic Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.0833
p.H2236P	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.0833
p.T2226I	SIDM01608	Endometrial Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	0.5966
p.T2226I	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.5966
p.A2220V	SIDM01608	Endometrial Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	0.2778
p.A2220V	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12270	Nucleoprotein TPR	LIG_APCC_ABBA_1	2222:2227	VTVFTE	APC,CDC20,FZR1	0.7634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTVFTE

Degron related mutations and impact score

Drug responses associated with TPR mutations

All proteins holding degron of VTVFTE