DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SPOP_SBC_1

Location: 2313:2317

E3 ligase: SPOP

DEGRON score: 0.5257

ASA_SCORE: 91.36

COIL: 0.9184

CONS_SCORE: 0.5137

DSS_SCORE: 0.8249

HELIX: 0.0412

FCONS_SCORE: 1.0106

RIG_SCORE: 0.5433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2316G	TCGA-49-AAR4	LUAD	TCGA	VDTSS	DEG_SPOP_SBC_1	0.6993
p.S2316G	DO218920	LUAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.6993
p.P2320S	TCGA-49-AAR9	LUAD	TCGA	VDTSS	DEG_SPOP_SBC_1	0.25
p.P2320S	DO218921	LUAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.25
p.Q2319H	TCGA-49-AAR9	LUAD	TCGA	VDTSS	DEG_SPOP_SBC_1	0.2778
p.Q2319H	DO218921	LUAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.S2316T	TCGA-CM-5861	COAD	TCGA	VDTSS	DEG_SPOP_SBC_1	0.6005
p.S2316T	DO7918	COAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.6005
p.S2312Y	DO229024	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.3056
p.T2315A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VDTSS	DEG_SPOP_SBC_1	0.7139
p.T2315A	ACH-000960	Leukemia	CCLE	VDTSS	DEG_SPOP_SBC_1	0.7139
p.T2315A	ACH-000982	Colon/Colorectal Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.7139
p.T2315A	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9909	More...
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.9544	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2313:2317	VDTSS	SPOP	0.5257	More...
P16435	NADPH--cytochrome P450 reductase	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.7465	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2527:2531	VDTSS	SPOP	0.9726	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9888	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1985:1989	VDTSS	SPOP	0.9585	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	713:717	VDTSS	SPOP	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons