DegronMD - P06454(PTMA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A33S	TCGA-49-4507	LUAD	TCGA	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.1111
p.G37W	TCGA-77-A5GF	LUSC	TCGA	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.2222
p.S9G	TCGA-D1-A1NZ	UCEC	TCGA	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.8104
p.D50H	TCGA-EK-A3GK	CESC	TCGA	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.2222
p.E47Q	DO48423	BLCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.3056
p.S33F	DO218796	BRCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.1111
p.E49K	DO6323	CESC	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.25
p.V16I	DO8938	COAD	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1667
p.W16L	DO228974	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1667
p.V12L	DO229015	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.A48S	DO229034	LICA	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.2778
p.R14L	DO229045	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2222
p.G5W	DO229009	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation blocking ubiquitination signal	0.75
p.A54S	DO25727	LUAD	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.1111
p.G51R	DO26092	LUAD	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.1944
p.A56P	DO52686	MALY	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.0556
p.S33A	DO218912	SKCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.1111
p.A11T	DO42608	UCEC	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.3056
p.G56E	ACH-000967	Colon/Colorectal Cancer	CCLE	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.0556
p.G56E	ACH-001199	Colon/Colorectal Cancer	CCLE	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.0556
p.G56E	SNU-C2B	large intestine	COSMIC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.0556
p.E41D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation altering degron motif	0.6758
p.G51E	SNU-C2B	large intestine	COSMIC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation rewiring degron network	0.1944
p.E42D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NEENGE	DEG_Kelch_Keap1_1	41:46	Mutation altering degron motif	0.5647

Kaplan plot for PTMA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTMA

UniProt ID: P06454

Entrez ID: 5757

Protein name: Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTMA in