DegronMD

Uniprot ID: P06454

Source protein: Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

Source gene: PTMA

Class: DEG_Kelch_Keap1_1

Location: 41:46

E3 ligase: KEAP1

DEGRON score: 0.9475

ASA_SCORE: 96.2333

COIL: 0.6247

CONS_SCORE: 0.9632

DSS_SCORE: 0.9392

HELIX: 0.3468

FCONS_SCORE: 1.1094

RIG_SCORE: 0.5523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A33S	TCGA-49-4507	LUAD	TCGA	NEENGE	DEG_Kelch_Keap1_1	0.1111
p.G37W	TCGA-77-A5GF	LUSC	TCGA	NEENGE	DEG_Kelch_Keap1_1	0.2222
p.D50H	TCGA-EK-A3GK	CESC	TCGA	NEENGE	DEG_Kelch_Keap1_1	0.2222
p.E47Q	DO48423	BLCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.3056
p.S33F	DO218796	BRCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.1111
p.E49K	DO6323	CESC	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.25
p.A48S	DO229034	LICA	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.2778
p.A54S	DO25727	LUAD	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.1111
p.G51R	DO26092	LUAD	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.1944
p.A56P	DO52686	MALY	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.0556
p.S33A	DO218912	SKCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.1111
p.G56E	ACH-000967	Colon/Colorectal Cancer	CCLE	NEENGE	DEG_Kelch_Keap1_1	0.0556
p.G56E	ACH-001199	Colon/Colorectal Cancer	CCLE	NEENGE	DEG_Kelch_Keap1_1	0.0556
p.G56E	SNU-C2B	large_intestine	COSMIC	NEENGE	DEG_Kelch_Keap1_1	0.0556
p.E41D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NEENGE	DEG_Kelch_Keap1_1	0.6758
p.G51E	SNU-C2B	large_intestine	COSMIC	NEENGE	DEG_Kelch_Keap1_1	0.1944
p.E42D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NEENGE	DEG_Kelch_Keap1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_Kelch_Keap1_1	41:46	NEENGE	KEAP1	0.9475	More...
Q13523	Serine/threonine-protein kinase PRP4 homolog	DEG_Kelch_Keap1_1	25:30	NEENGE	KEAP1	0.8745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons