DegronMD

Uniprot ID: Q13523

Source protein: Serine/threonine-protein kinase PRP4 homolog

Source gene: PRPF4B

Class: DEG_Kelch_Keap1_1

Location: 25:30

E3 ligase: KEAP1

DEGRON score: 0.8745

ASA_SCORE: 112.25

COIL: 0.7995

CONS_SCORE: 0.3933

DSS_SCORE: 0.7473

HELIX: 0.1805

FCONS_SCORE: 0.9836

RIG_SCORE: 0.5722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E16K	TCGA-AX-A05W	UCEC	TCGA	NEENGE	DEG_Kelch_Keap1_1	0.0833
p.Q37E	TCGA-E7-A6MD	BLCA	TCGA	NEENGE	DEG_Kelch_Keap1_1	0.1389
p.A18S	TCGA-W3-A828	SKCM	TCGA	NEENGE	DEG_Kelch_Keap1_1	0.1389
p.Q23E	DO219015	BLCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.7222
p.K22R	DO50907	LICA	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.3611
p.R28C	DO41752	UCEC	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.8301
p.H29Y	DO43763	UCEC	ICGC	NEENGE	DEG_Kelch_Keap1_1	0.7229
p.E27Q	ACH-001408	Bladder Cancer	CCLE	NEENGE	DEG_Kelch_Keap1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_Kelch_Keap1_1	41:46	NEENGE	KEAP1	0.9475	More...
Q13523	Serine/threonine-protein kinase PRP4 homolog	DEG_Kelch_Keap1_1	25:30	NEENGE	KEAP1	0.8745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons