DegronMD - Q13523(PRPF4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G336V	TCGA-91-6828	LUAD	TCGA	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation altering degron motif	0.6421
p.G336V	DO26150	LUAD	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation altering degron motif	0.6421
p.S87F	TCGA-A1-A0SH	BRCA	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.5278
p.S87F	DO1261	BRCA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.5278
p.S93Y	TCGA-AG-A002	READ	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.6944
p.S93Y	DO234205	ESAD	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.6944
p.P346H	TCGA-AP-A059	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.1667
p.E16K	TCGA-AX-A05W	UCEC	TCGA	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation rewiring degron network	0.0833
p.L109V	TCGA-CM-6674	COAD	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1944
p.L109V	DO10092	COAD	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1944
p.P350S	TCGA-D3-A8GI	SKCM	TCGA	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.0556
p.A114S	TCGA-DX-A6YV	SARC	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0556
p.A114S	DO220011	SARC	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0556
p.Q37E	TCGA-E7-A6MD	BLCA	TCGA	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation rewiring degron network	0.1389
p.A18S	TCGA-W3-A828	SKCM	TCGA	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation rewiring degron network	0.1389
p.Q23E	DO219015	BLCA	ICGC	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation blocking phosphorylation signal	0.7222
p.E96K	DO225124	BRCA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.7022
p.D107H	DO6128	BRCA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.25
p.G347V	DO228974	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.1389
p.M111I	DO228974	LICA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation blocking ubiquitination signal	0.5833
p.S349I	DO229009	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation blocking phosphorylation signal	0.5278
p.K22R	DO50907	LICA	ICGC	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation substituting flanking lysine	0.3611
p.P336S	DO220903	MELA	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation altering degron motif	0.6752
p.P336S	DO50284	SKCM	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation altering degron motif	0.6752
p.G347D	DO232224	PBCA	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.1389
p.R28C	DO41752	UCEC	ICGC	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation altering degron motif	0.8301
p.H29Y	DO43763	UCEC	ICGC	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation altering degron motif	0.7229
p.P332H	DO41361	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.2222
p.K89E	SIDM00262	Ewing's Sarcoma	GDSC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation substituting flanking lysine	0.25
p.K89E	ACH-002107	Bone Cancer	CCLE	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation substituting flanking lysine	0.25
p.K89E	ES6	bone	COSMIC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation substituting flanking lysine	0.25
p.R113K	SIDM00032	Bladder Carcinoma	GDSC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0833
p.R113K	ACH-000839	Bladder Cancer	CCLE	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0833
p.R113K	SCaBER	urinary tract	COSMIC	KRTKLDDLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0833
p.E27Q	ACH-001408	Bladder Cancer	CCLE	NEENGE	DEG_Kelch_Keap1_1	25:30	Mutation altering degron motif	0.6744

Kaplan plot for PRPF4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRPF4B

UniProt ID: Q13523

Entrez ID: 8899

Protein name: Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRPF4B in