DegronMD

Uniprot ID: Q13523

Source protein: Serine/threonine-protein kinase PRP4 homolog

Source gene: PRPF4B

Class: DEG_APCC_KENBOX_2

Location: 336:340

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9861

ASA_SCORE: 112.46

COIL: 0.9208

CONS_SCORE: 0.4303

DSS_SCORE: 0.8682

HELIX: 0.043

FCONS_SCORE: 1.0063

RIG_SCORE: 0.4698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G336V	TCGA-91-6828	LUAD	TCGA	GKENR	DEG_APCC_KENBOX_2	0.6421
p.G336V	DO26150	LUAD	ICGC	GKENR	DEG_APCC_KENBOX_2	0.6421
p.P346H	TCGA-AP-A059	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	0.1667
p.P350S	TCGA-D3-A8GI	SKCM	TCGA	GKENR	DEG_APCC_KENBOX_2	0.0556
p.G347V	DO228974	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.1389
p.S349I	DO229009	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.5278
p.P336S	DO220903	MELA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.6752
p.P336S	DO50284	SKCM	ICGC	GKENR	DEG_APCC_KENBOX_2	0.6752
p.G347D	DO232224	PBCA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.1389
p.P332H	DO41361	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13523	Serine/threonine-protein kinase PRP4 homolog	DEG_APCC_KENBOX_2	336:340	GKENR	APC,CDC20,FZR1	0.9861	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_APCC_KENBOX_2	120:124	GKENR	APC,CDC20,FZR1	0.7271	More...
Q5JSZ5	Protein PRRC2B	DEG_APCC_KENBOX_2	326:330	GKENR	APC,CDC20,FZR1	0.9166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons