DegronMD

Uniprot ID: Q14157

Source protein: Ubiquitin-associated protein 2-like

Source gene: UBAP2L

Class: DEG_APCC_KENBOX_2

Location: 120:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7271

ASA_SCORE: 100.3

COIL: 0.775

CONS_SCORE: 0.5614

DSS_SCORE: 0.7243

HELIX: 0.1878

FCONS_SCORE: 1.0696

RIG_SCORE: 0.6174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R134C	TCGA-76-4927	GBM	TCGA	GKENR	DEG_APCC_KENBOX_2	0.0556
p.R134C	DO12556	GBM	ICGC	GKENR	DEG_APCC_KENBOX_2	0.0556
p.R134C	SIDM01164	Glioma	GDSC	GKENR	DEG_APCC_KENBOX_2	0.0556
p.R134C	ACH-000883	Brain Cancer	CCLE	GKENR	DEG_APCC_KENBOX_2	0.0556
p.R134C	SW1783	central_nervous_system	COSMIC	GKENR	DEG_APCC_KENBOX_2	0.0556
p.R126Q	TCGA-B5-A1N2	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	0.2778
p.R126Q	DO41602	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	0.2778
p.E118K	TCGA-D3-A51T	SKCM	TCGA	GKENR	DEG_APCC_KENBOX_2	0.2778
p.E118K	DO47389	SKCM	ICGC	GKENR	DEG_APCC_KENBOX_2	0.2778
p.D127N	TCGA-DA-A95Y	SKCM	TCGA	GKENR	DEG_APCC_KENBOX_2	0.25
p.D127N	DO223908	SKCM	ICGC	GKENR	DEG_APCC_KENBOX_2	0.25
p.T114M	DO227536	COCA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.1667
p.R132Q	DO227979	COCA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.1111
p.D110Y	DO229022	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.0556
p.G120C	DO229045	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.6489
p.R124Q	DO229050	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.6218
p.R132L	SIDM00576	Acute Myeloid Leukemia	GDSC	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R132L	ACH-002290	Leukemia	CCLE	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R132L	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	GKENR	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13523	Serine/threonine-protein kinase PRP4 homolog	DEG_APCC_KENBOX_2	336:340	GKENR	APC,CDC20,FZR1	0.9861	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_APCC_KENBOX_2	120:124	GKENR	APC,CDC20,FZR1	0.7271	More...
Q5JSZ5	Protein PRRC2B	DEG_APCC_KENBOX_2	326:330	GKENR	APC,CDC20,FZR1	0.9166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons