DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_APCC_KENBOX_2

Location: 326:330

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9166

ASA_SCORE: 102.86

COIL: 0.712

CONS_SCORE: 0.6024

DSS_SCORE: 0.6082

HELIX: 0.2632

FCONS_SCORE: 0.9955

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q318H	TCGA-17-Z055	LUAD	TCGA	GKENR	DEG_APCC_KENBOX_2	0.1111
p.G326R	TCGA-AX-A1CE	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	0.6457
p.G326R	DO42280	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	0.6457
p.G326R	SIDM00217	Colorectal Carcinoma	GDSC	GKENR	DEG_APCC_KENBOX_2	0.6457
p.G326R	SNU-1040	large_intestine	COSMIC	GKENR	DEG_APCC_KENBOX_2	0.6457
p.R338C	TCGA-EO-A3AU	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R338C	DO43827	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R338C	SIDM00614	Hepatocellular Carcinoma	GDSC	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R338C	ACH-000848	Liver Cancer	CCLE	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R338C	JHH-7	liver	COSMIC	GKENR	DEG_APCC_KENBOX_2	0.1111
p.R317I	TCGA-IN-A6RL	STAD	TCGA	GKENR	DEG_APCC_KENBOX_2	0.0833
p.R317I	DO51738	STAD	ICGC	GKENR	DEG_APCC_KENBOX_2	0.0833
p.R335H	TCGA-XR-A8TC	LIHC	TCGA	GKENR	DEG_APCC_KENBOX_2	0.1944
p.R335H	DO223920	LIHC	ICGC	GKENR	DEG_APCC_KENBOX_2	0.1944
p.D323N	DO234467	ESAD	ICGC	GKENR	DEG_APCC_KENBOX_2	0.25
p.L333S	DO233869	GACA	ICGC	GKENR	DEG_APCC_KENBOX_2	0.25
p.R338H	ACH-001719	Ovarian Cancer	CCLE	GKENR	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13523	Serine/threonine-protein kinase PRP4 homolog	DEG_APCC_KENBOX_2	336:340	GKENR	APC,CDC20,FZR1	0.9861	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_APCC_KENBOX_2	120:124	GKENR	APC,CDC20,FZR1	0.7271	More...
Q5JSZ5	Protein PRRC2B	DEG_APCC_KENBOX_2	326:330	GKENR	APC,CDC20,FZR1	0.9166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons