DegronMD

Uniprot ID: Q13523

Source protein: Serine/threonine-protein kinase PRP4 homolog

Source gene: PRPF4B

Class: DEG_APCC_DBOX_1

Location: 96:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9854

ASA_SCORE: 89.9111

COIL: 0.4314

CONS_SCORE: 0.3842

DSS_SCORE: 0.433

HELIX: 0.5576

FCONS_SCORE: 0.9867

RIG_SCORE: 0.7833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S87F	TCGA-A1-A0SH	BRCA	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	0.5278
p.S87F	DO1261	BRCA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.5278
p.S93Y	TCGA-AG-A002	READ	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	0.6944
p.S93Y	DO234205	ESAD	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.6944
p.L109V	TCGA-CM-6674	COAD	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	0.1944
p.L109V	DO10092	COAD	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.1944
p.A114S	TCGA-DX-A6YV	SARC	TCGA	KRTKLDDLA	DEG_APCC_DBOX_1	0.0556
p.A114S	DO220011	SARC	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.0556
p.E96K	DO225124	BRCA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.7022
p.D107H	DO6128	BRCA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.25
p.M111I	DO228974	LICA	ICGC	KRTKLDDLA	DEG_APCC_DBOX_1	0.5833
p.K89E	SIDM00262	Ewing's Sarcoma	GDSC	KRTKLDDLA	DEG_APCC_DBOX_1	0.25
p.K89E	ACH-002107	Bone Cancer	CCLE	KRTKLDDLA	DEG_APCC_DBOX_1	0.25
p.K89E	ES6	bone	COSMIC	KRTKLDDLA	DEG_APCC_DBOX_1	0.25
p.R113K	SIDM00032	Bladder Carcinoma	GDSC	KRTKLDDLA	DEG_APCC_DBOX_1	0.0833
p.R113K	ACH-000839	Bladder Cancer	CCLE	KRTKLDDLA	DEG_APCC_DBOX_1	0.0833
p.R113K	SCaBER	urinary_tract	COSMIC	KRTKLDDLA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13523	Serine/threonine-protein kinase PRP4 homolog	DEG_APCC_DBOX_1	96:104	KRTKLDDLA	APC,CDC20,FZR1	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons