DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_SPOP_SBC_1

Location: 2527:2531

E3 ligase: SPOP

DEGRON score: 0.9726

ASA_SCORE: 84.8

COIL: 0.9046

CONS_SCORE: 0.501

DSS_SCORE: 0.5396

HELIX: 0.061

FCONS_SCORE: 1.0491

RIG_SCORE: 0.6857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2526A	TCGA-CZ-4859	KIRC	TCGA	VDTSS	DEG_SPOP_SBC_1	0.3056
p.D2526A	DO18602	KIRC	ICGC	VDTSS	DEG_SPOP_SBC_1	0.3056
p.P2541L	TCGA-DA-A1I0	SKCM	TCGA	VDTSS	DEG_SPOP_SBC_1	0.0556
p.P2541L	DO37719	SKCM	ICGC	VDTSS	DEG_SPOP_SBC_1	0.0556
p.P2541H	TCGA-DU-6392	LGG	TCGA	VDTSS	DEG_SPOP_SBC_1	0.0556
p.P2541H	DO22237	LGG	ICGC	VDTSS	DEG_SPOP_SBC_1	0.0556
p.D2521N	TCGA-G2-A3VY	BLCA	TCGA	VDTSS	DEG_SPOP_SBC_1	0.1667
p.D2521N	DO590	BLCA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1667
p.D2521H	TCGA-IR-A3LK	CESC	TCGA	VDTSS	DEG_SPOP_SBC_1	0.1667
p.D2521H	DO44299	CESC	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1667
p.P2519L	TCGA-QQ-A8VG	SARC	TCGA	VDTSS	DEG_SPOP_SBC_1	0.1111
p.P2519L	DO220260	SARC	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1111
p.S2530G	SIDM00693	Bladder Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	0.8104
p.S2530G	SIDM01732	Non-Cancerous	GDSC	VDTSS	DEG_SPOP_SBC_1	0.8104
p.S2530G	ACH-000396	Bladder Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.8104
p.S2530G	ACH-001385	Head and Neck Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.8104
p.S2530G	ACH-002379	Non-Cancerous	CCLE	VDTSS	DEG_SPOP_SBC_1	0.8104
p.S2530G	RPMI-2650	upper_aerodigestive_tract	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.8104
p.S2532N	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	0.3056
p.S2532N	ACH-000511	Lung Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9909	More...
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.9544	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2313:2317	VDTSS	SPOP	0.5257	More...
P16435	NADPH--cytochrome P450 reductase	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.7465	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2527:2531	VDTSS	SPOP	0.9726	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9888	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1985:1989	VDTSS	SPOP	0.9585	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	713:717	VDTSS	SPOP	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons