DegronMD - Q96T58(SPEN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2997K	TCGA-05-4395	LUAD	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7022
p.E2997K	DO25444	LUAD	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7022
p.S1571N	TCGA-06-5416	GBM	TCGA	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation altering degron motif	0.7069
p.S1571N	DO10880	GBM	ICGC	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation altering degron motif	0.7069
p.R2624G	TCGA-17-Z062	LUAD	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.6457
p.Q2244H	TCGA-34-8454	LUSC	TCGA	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.1944
p.Q2244H	DO50094	LUSC	ICGC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.1944
p.Q2386H	TCGA-34-8454	LUSC	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.2222
p.Q2386H	DO50094	LUSC	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.2222
p.P1735S	TCGA-4Z-AA7W	BLCA	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation altering degron motif	0.6752
p.P1735S	DO218984	BLCA	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation altering degron motif	0.6752
p.R762W	TCGA-55-8506	LUAD	TCGA	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0833
p.R762W	DO45390	LUAD	ICGC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0833
p.P2612S	TCGA-5L-AAT1	BRCA	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.2778
p.P2612S	DO219594	BRCA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.2778
p.R781H	TCGA-60-2714	LUSC	TCGA	PPRY	ITCH	771:774	Mutation rewiring degron network	0.1389
p.R781H	DO26530	LUSC	ICGC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.1389
p.D1574N	TCGA-86-8056	LUAD	TCGA	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.3056
p.D1574N	DO24950	LUAD	ICGC	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.3056
p.I2618M	TCGA-A5-A0GP	UCEC	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.6507
p.I2618M	DO41109	UCEC	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.6507
p.R784H	TCGA-A6-5661	COAD	TCGA	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0556
p.R784H	TCGA-AX-A3G8	UCEC	TCGA	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0556
p.R784H	DO8634	COAD	ICGC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0556
p.R784H	DO229050	LICA	ICGC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0556
p.R784H	DO41014	UCEC	ICGC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0556
p.R784H	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.0556
p.P1728L	TCGA-AD-5900	COAD	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1389
p.P1728L	DO8514	COAD	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1389
p.Y1730S	TCGA-AG-A002	READ	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1944
p.S2411L	TCGA-AJ-A3EL	UCEC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation blocking phosphorylation signal	0.6111
p.S2411L	TCGA-EO-A22R	UCEC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation blocking phosphorylation signal	0.6111
p.S2411L	TCGA-FR-A726	SKCM	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation blocking phosphorylation signal	0.6111
p.S2411L	DO48665	SKCM	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation blocking phosphorylation signal	0.6111
p.S2411L	DO41542	UCEC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation blocking phosphorylation signal	0.6111
p.S2411L	DO42713	UCEC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation blocking phosphorylation signal	0.6111
p.D2401N	TCGA-AR-A1AO	BRCA	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.2222
p.D2401N	DO4443	BRCA	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.2222
p.S2227Y	TCGA-AX-A2HC	UCEC	TCGA	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.0833
p.S2227Y	DO41572	UCEC	ICGC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.0833
p.S2387N	TCGA-AZ-4315	COAD	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation blocking phosphorylation signal	0.6944
p.S2387N	DO8842	COAD	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation blocking phosphorylation signal	0.6944
p.P2236S	TCGA-B0-4827	KIRC	TCGA	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.6752
p.P2236S	DO16158	KIRC	ICGC	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.6752
p.L1582P	TCGA-B5-A3FA	UCEC	TCGA	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.0833
p.L1582P	DO52402	UCEC	ICGC	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.0833
p.V2562A	TCGA-BR-8680	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.0833
p.V2562A	DO47769	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.0833
p.V3013D	TCGA-CD-A4MG	STAD	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1111
p.V3013D	DO48009	STAD	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1111
p.R2624Q	TCGA-CG-5720	STAD	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.6218
p.R2624Q	DO38623	STAD	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.6218
p.P2236L	TCGA-CK-4951	COAD	TCGA	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.7582
p.P2236L	DO10582	COAD	ICGC	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.7582
p.S765N	TCGA-CN-4727	HNSC	TCGA	PPRY	ITCH	771:774	Mutation blocking phosphorylation signal	0.6111
p.S765N	DO14258	HNSC	ICGC	PPRY	ITCH	771:774	Mutation blocking phosphorylation signal	0.6111
p.P2428S	TCGA-CV-7568	HNSC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2222
p.P2428S	DO14160	HNSC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2222
p.D2526A	TCGA-CZ-4859	KIRC	TCGA	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.3056
p.D2526A	DO18602	KIRC	ICGC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.3056
p.T3476I	TCGA-D1-A17B	UCEC	TCGA	VLPHTE	LIG_APCC_ABBA_1	3472:3477	Mutation altering degron motif	0.5966
p.T3476I	DO43017	UCEC	ICGC	VLPHTE	LIG_APCC_ABBA_1	3472:3477	Mutation altering degron motif	0.5966
p.P2541L	TCGA-DA-A1I0	SKCM	TCGA	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.0556
p.P2541L	TCGA-DA-A1I0	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.P2541L	DO37719	SKCM	ICGC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.0556
p.P2541L	DO37719	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.S1747N	TCGA-DF-A2KU	UCEC	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1667
p.S1747N	DO223286	UCEC	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1667
p.P2541H	TCGA-DU-6392	LGG	TCGA	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.0556
p.P2541H	TCGA-DU-6392	LGG	TCGA	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.P2541H	DO22237	LGG	ICGC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.0556
p.P2541H	DO22237	LGG	ICGC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.P1728A	TCGA-EB-A3XC	SKCM	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1389
p.P1728A	DO37579	SKCM	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.1389
p.S2553G	TCGA-EE-A29S	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.6993
p.S2553G	DO37936	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.6993
p.S2553G	SIDM00454	Rhabdomyosarcoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.6993
p.S2553G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.6993
p.P3002H	TCGA-EE-A2M8	SKCM	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7694
p.P3002H	DO38075	SKCM	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7694
p.S1741L	TCGA-EE-A2MP	SKCM	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation altering degron motif	0.7667
p.S1741L	DO37818	SKCM	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation altering degron motif	0.7667
p.R3011Q	TCGA-EO-A3AV	UCEC	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	DO52412	UCEC	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	SIDM00425	Ovarian Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	SIDM00118	Colorectal Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	SIDM01695	Acute Myeloid Leukemia	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	SIDM01445	Gastric Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	HCC2998	large intestine	COSMIC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011Q	OVTOKO	ovary	COSMIC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.S2426Y	TCGA-EO-A3KX	UCEC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2778
p.S2426Y	DO219774	UCEC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2778
p.S2403R	TCGA-EY-A1GQ	UCEC	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.1667
p.S2403R	DO43090	UCEC	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.1667
p.S3003L	TCGA-FD-A6TB	BLCA	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	TCGA-HU-A4H5	STAD	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	DO51879	BLCA	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	DO232761	PBCA	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	DO47727	STAD	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	SIDM00358	Gastric Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	ACH-000144	Gastric Cancer	CCLE	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	ACH-001409	Bladder Cancer	CCLE	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.S3003L	RERF-GC-1B	stomach	COSMIC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation altering degron motif	0.7667
p.D2521N	TCGA-G2-A3VY	BLCA	TCGA	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.1667
p.D2521N	DO590	BLCA	ICGC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.1667
p.E2231Q	TCGA-GD-A6C6	BLCA	TCGA	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.1944
p.E2231Q	DO48504	BLCA	ICGC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.1944
p.P3008S	TCGA-GF-A6C9	SKCM	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.25
p.P3008S	DO51254	SKCM	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.25
p.I3007L	TCGA-GU-A767	BLCA	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.2778
p.I3007L	DO51892	BLCA	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.2778
p.D1726N	TCGA-HE-A5NL	KIRP	TCGA	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.0833
p.D1726N	DO44528	KIRP	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.0833
p.S765C	TCGA-HU-A4GH	STAD	TCGA	PPRY	ITCH	771:774	Mutation blocking phosphorylation signal	0.6111
p.S765C	DO47743	STAD	ICGC	PPRY	ITCH	771:774	Mutation blocking phosphorylation signal	0.6111
p.D2521H	TCGA-IR-A3LK	CESC	TCGA	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.1667
p.D2521H	DO44299	CESC	ICGC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.1667
p.E1578Q	TCGA-JW-A5VL	CESC	TCGA	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.1944
p.E1578Q	DO49976	CESC	ICGC	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.1944
p.S2400Y	TCGA-K4-A5RH	BLCA	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.25
p.S2400Y	DO219028	BLCA	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.25
p.R3011L	TCGA-KQ-A41N	BLCA	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.R3011L	DO223588	BLCA	ICGC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.1667
p.P2519L	TCGA-QQ-A8VG	SARC	TCGA	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.1111
p.P2519L	DO220260	SARC	ICGC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.1111
p.A3009G	TCGA-QT-A5XO	PCPG	TCGA	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.2222
p.S2426T	DO223141	ESCA	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2778
p.R2624L	DO228978	LICA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.7316
p.R781L	DO228971	LICA	ICGC	PPRY	ITCH	771:774	Mutation rewiring degron network	0.1389
p.V2621F	DO229015	LICA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.5957
p.Q2635H	DO229035	LICA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.1111
p.P3456S	DO229054	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	3459:3463	Mutation rewiring degron network	0.25
p.S2305I	DO229006	LICA	ICGC	SSETSHSVPEA	DEG_COP1_1	2305:2315	Mutation altering degron motif	0.7341
p.G3464A	DO230990	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	3459:3463	Mutation rewiring degron network	0.3056
p.G3464A	DO230990	LUSC	ICGC	VLPHTE	LIG_APCC_ABBA_1	3472:3477	Mutation rewiring degron network	0.1111
p.P2240S	DO222702	MELA	ICGC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.G1725D	DO46380	OV	ICGC	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation rewiring degron network	0.0556
p.P2240L	SIDM00425	Ovarian Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00437	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00535	Chondrosarcoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00619	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00580	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00368	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01695	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01470	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01611	Endometrial Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01445	Gastric Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM00173	Head and Neck Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01473	Plasma Cell Myeloma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.P2240L	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation rewiring degron network	0.3056
p.Q2382P	SIDM01062	Breast Carcinoma	GDSC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.1111
p.Q2382P	ACH-000643	Breast Cancer	CCLE	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.1111
p.Q2382P	HDQ-P1	breast	COSMIC	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.1111
p.S2628R	SIDM00602	Gastric Carcinoma	GDSC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.3056
p.S2628R	ACH-000919	Gastric Cancer	CCLE	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.3056
p.S2628R	IM-95	stomach	COSMIC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.3056
p.S2530G	SIDM00693	Bladder Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation altering degron motif	0.8104
p.S2530G	SIDM01732	Non-Cancerous	GDSC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation altering degron motif	0.8104
p.S2530G	ACH-000396	Bladder Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation altering degron motif	0.8104
p.S2530G	ACH-001385	Head and Neck Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation altering degron motif	0.8104
p.S2530G	ACH-002379	Non-Cancerous	CCLE	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation altering degron motif	0.8104
p.S2530G	RPMI-2650	upper aerodigestive tract	COSMIC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation altering degron motif	0.8104
p.P2428T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2222
p.P2428T	ACH-002256	Leukemia	CCLE	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2222
p.P2428T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2222
p.P2434L	SIDM01041	Esophageal Carcinoma	GDSC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.0556
p.P2434L	ACH-001500	Esophageal Cancer	CCLE	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.0556
p.P2434L	FLO-1	oesophagus	COSMIC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.0556
p.Q3450H	SIDM00156	Neuroblastoma	GDSC	VPTTS	DEG_SPOP_SBC_1	3459:3463	Mutation rewiring degron network	0.0833
p.Q3450H	ACH-002285	Neuroblastoma	CCLE	VPTTS	DEG_SPOP_SBC_1	3459:3463	Mutation rewiring degron network	0.0833
p.Q3450H	NB7	autonomic ganglia	COSMIC	VPTTS	DEG_SPOP_SBC_1	3459:3463	Mutation rewiring degron network	0.0833
p.P3008Q	SIDM00568	Gastric Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.25
p.P3008Q	ACH-000247	Gastric Cancer	CCLE	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.25
p.P3008Q	OCUM-1	stomach	COSMIC	TEVNHVPSGP	DEG_COP1_1	2996:3005	Mutation rewiring degron network	0.25
p.S2426F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	2417:2424	Mutation rewiring degron network	0.2778
p.E2560K	SIDM00997	Thyroid Gland Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.E2560K	SIDM00970	Bladder Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.E2560K	ACH-002235	Bladder Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.E2560K	DSH1	urinary tract	COSMIC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.E2560K	8305C	thyroid	COSMIC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.P2238L	SIDM00217	Colorectal Carcinoma	GDSC	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.6471
p.P2238L	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.6471
p.P2238L	SNU-1040	large intestine	COSMIC	PPPY	ITCH	2236:2239	Mutation altering degron motif	0.6471
p.A2546V	SIDM00217	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.25
p.A2546V	ACH-000999	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.25
p.A2546V	SNU-1040	large intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.25
p.P2561S	SIDM00150	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.P2561S	ACH-000969	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.P2561S	KM12	large intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.S2532N	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.3056
p.S2532N	ACH-000511	Lung Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	2527:2531	Mutation rewiring degron network	0.3056
p.A2615V	SIDM01592	Breast Carcinoma	GDSC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation altering degron motif	0.6936
p.D2630V	SIDM01611	Endometrial Carcinoma	GDSC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.25
p.D2630V	ACH-000996	Endometrial/Uterine Cancer	CCLE	IAPKITSVISRMPV	DEG_ODPH_VHL_1	2614:2627	Mutation rewiring degron network	0.25
p.P2561A	SIDM01473	Plasma Cell Myeloma	GDSC	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.P2561A	ACH-000541	Myeloma	CCLE	VTSTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.E1567Q	ACH-000975	Lung Cancer	CCLE	ANSTT	DEG_SPOP_SBC_1	1569:1573	Mutation rewiring degron network	0.2778
p.T1737P	ACH-001303	Neuroblastoma	CCLE	PPTPGAS	DEG_SCF_FBW7_1	1735:1741	Mutation altering degron motif	0.8142
p.Q2396R	ACH-001664	Gastric Cancer	CCLE	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation altering degron motif	0.6218
p.T2399A	ACH-001719	Ovarian Cancer	CCLE	PHSTPPQS	DEG_SCF_FBW7_1	2390:2397	Mutation rewiring degron network	0.2778
p.S2306G	ACH-002027	Endometrial/Uterine Cancer	CCLE	SSETSHSVPEA	DEG_COP1_1	2305:2315	Mutation altering degron motif	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPEN

UniProt ID: Q96T58

Entrez ID: 23013

Protein name: Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPEN in