DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_COP1_1

Location: 2996:3005

E3 ligase: COP1

DEGRON score: 0.9877

ASA_SCORE: 99.14

COIL: 0.9597

CONS_SCORE: 0.3649

DSS_SCORE: 0.6315

HELIX: 0.0188

FCONS_SCORE: 0.9748

RIG_SCORE: 0.6138

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2997K	TCGA-05-4395	LUAD	TCGA	TEVNHVPSGP	DEG_COP1_1	0.7022
p.E2997K	DO25444	LUAD	ICGC	TEVNHVPSGP	DEG_COP1_1	0.7022
p.V3013D	TCGA-CD-A4MG	STAD	TCGA	TEVNHVPSGP	DEG_COP1_1	0.1111
p.V3013D	DO48009	STAD	ICGC	TEVNHVPSGP	DEG_COP1_1	0.1111
p.P3002H	TCGA-EE-A2M8	SKCM	TCGA	TEVNHVPSGP	DEG_COP1_1	0.7694
p.P3002H	DO38075	SKCM	ICGC	TEVNHVPSGP	DEG_COP1_1	0.7694
p.R3011Q	TCGA-EO-A3AV	UCEC	TCGA	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	DO52412	UCEC	ICGC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	SIDM00425	Ovarian Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	SIDM00118	Colorectal Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	SIDM01695	Acute Myeloid Leukemia	GDSC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	SIDM01445	Gastric Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	HCC2998	large_intestine	COSMIC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011Q	OVTOKO	ovary	COSMIC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.S3003L	TCGA-FD-A6TB	BLCA	TCGA	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	TCGA-HU-A4H5	STAD	TCGA	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	DO51879	BLCA	ICGC	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	DO232761	PBCA	ICGC	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	DO47727	STAD	ICGC	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	SIDM00358	Gastric Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	ACH-000144	Gastric Cancer	CCLE	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	ACH-001409	Bladder Cancer	CCLE	TEVNHVPSGP	DEG_COP1_1	0.7667
p.S3003L	RERF-GC-1B	stomach	COSMIC	TEVNHVPSGP	DEG_COP1_1	0.7667
p.P3008S	TCGA-GF-A6C9	SKCM	TCGA	TEVNHVPSGP	DEG_COP1_1	0.25
p.P3008S	DO51254	SKCM	ICGC	TEVNHVPSGP	DEG_COP1_1	0.25
p.I3007L	TCGA-GU-A767	BLCA	TCGA	TEVNHVPSGP	DEG_COP1_1	0.2778
p.I3007L	DO51892	BLCA	ICGC	TEVNHVPSGP	DEG_COP1_1	0.2778
p.R3011L	TCGA-KQ-A41N	BLCA	TCGA	TEVNHVPSGP	DEG_COP1_1	0.1667
p.R3011L	DO223588	BLCA	ICGC	TEVNHVPSGP	DEG_COP1_1	0.1667
p.A3009G	TCGA-QT-A5XO	PCPG	TCGA	TEVNHVPSGP	DEG_COP1_1	0.2222
p.P3008Q	SIDM00568	Gastric Carcinoma	GDSC	TEVNHVPSGP	DEG_COP1_1	0.25
p.P3008Q	ACH-000247	Gastric Cancer	CCLE	TEVNHVPSGP	DEG_COP1_1	0.25
p.P3008Q	OCUM-1	stomach	COSMIC	TEVNHVPSGP	DEG_COP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEVNHVPSGP

Degron related mutations and impact score

Drug responses associated with SPEN mutations

All proteins holding degron of TEVNHVPSGP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T58	Msx2-interacting protein	DEG_COP1_1	2996:3005	TEVNHVPSGP	COP1	0.9877	More...