DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_SCF_FBW7_1

Location: 1735:1741

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 79.0286

COIL: 0.9384

CONS_SCORE: 0.4048

DSS_SCORE: 0.7772

HELIX: 0.0451

FCONS_SCORE: 1.2345

RIG_SCORE: 0.5536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1735S	TCGA-4Z-AA7W	BLCA	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.6752
p.P1735S	DO218984	BLCA	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.6752
p.P1728L	TCGA-AD-5900	COAD	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.1389
p.P1728L	DO8514	COAD	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.1389
p.Y1730S	TCGA-AG-A002	READ	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.1944
p.S1747N	TCGA-DF-A2KU	UCEC	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.1667
p.S1747N	DO223286	UCEC	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.1667
p.P1728A	TCGA-EB-A3XC	SKCM	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.1389
p.P1728A	DO37579	SKCM	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.1389
p.S1741L	TCGA-EE-A2MP	SKCM	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.7667
p.S1741L	DO37818	SKCM	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.7667
p.D1726N	TCGA-HE-A5NL	KIRP	TCGA	PPTPGAS	DEG_SCF_FBW7_1	0.0833
p.D1726N	DO44528	KIRP	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.0833
p.G1725D	DO46380	OV	ICGC	PPTPGAS	DEG_SCF_FBW7_1	0.0556
p.T1737P	ACH-001303	Neuroblastoma	CCLE	PPTPGAS	DEG_SCF_FBW7_1	0.8142

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T58	Msx2-interacting protein	DEG_SCF_FBW7_1	1735:1741	PPTPGAS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons